Hastar Nurcan, Arslan Elif, Guler Mustafa O, Tekinay Ayse B
Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, 06800, Turkey.
Institute for Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA.
Adv Exp Med Biol. 2017;1030:155-166. doi: 10.1007/978-3-319-66095-0_7.
Cartilaginous tissue requires structural and metabolic support after traumatic or chronic injuries because of its limited capacity for regeneration. However, current techniques for cartilage regeneration are either invasive or ineffective for long-term repair. Developing alternative approaches to regenerate cartilage tissue is needed. Therefore, versatile scaffolds formed by biomaterials are promising tools for cartilage regeneration. Bioactive scaffolds further enhance the utility in a broad range of applications including the treatment of major cartilage defects. This chapter provides an overview of cartilage tissue, tissue defects, and the methods used for regeneration, with emphasis on peptide scaffold materials that can be used to supplement or replace current medical treatment options.
由于软骨组织的再生能力有限，在遭受创伤或慢性损伤后需要结构和代谢支持。然而，目前的软骨再生技术要么具有侵入性，要么对长期修复无效。因此，需要开发替代方法来再生软骨组织。由生物材料形成的多功能支架是软骨再生的有前景的工具。生物活性支架进一步提高了其在包括治疗主要软骨缺损在内的广泛应用中的效用。本章概述了软骨组织、组织缺损以及用于再生的方法，重点介绍了可用于补充或替代当前医疗选择的肽支架材料。
