Schulte-Wissermann H, Borzy M S, Albrecht R, Hong R
Scand J Immunol. 1979;9(1):45-52. doi: 10.1111/j.1365-3083.1979.tb02705.x.
Human thymus epithelium, depleted of thymocytes and macrophages by means of organ culture, was used in chemotaxis experiments with peripheral blood cells. Such cultured thymus epithelium can attract specifically macrophages and basophils. T-lymphocytes were attracted only by short-term (8 day) cultured thymus tissue which still retains some of the original macrophage population. Thymic macrophages formed rosette structures with thymocytes. In other experiments 'activated' rabbit macrophages had the capability to destroy thymocytes, whether autochthonous or allogeneic. The possible role of macrophages and basophils in thymus function is discussed.
通过器官培养去除胸腺细胞和巨噬细胞的人胸腺上皮，被用于外周血细胞的趋化性实验。这种培养的胸腺上皮能特异性吸引巨噬细胞和嗜碱性粒细胞。只有短期（8天）培养且仍保留一些原始巨噬细胞群体的胸腺组织才能吸引T淋巴细胞。胸腺巨噬细胞与胸腺细胞形成玫瑰花结结构。在其他实验中，“活化”的兔巨噬细胞有能力破坏胸腺细胞，无论是自体的还是异体的。本文讨论了巨噬细胞和嗜碱性粒细胞在胸腺功能中的可能作用。
