From the Departments of Radiodiagnosis, and.
Nuclear Medicine, Basavatarakam Indo American Cancer Hospital & Research Institute, Hyderabad, Telangana, India.
Clin Nucl Med. 2019 Jul;44(7):e431-e432. doi: 10.1097/RLU.0000000000002619.
A 72-year-old man with history of itching for 8 months presented with an ill-defined, ulcerated, eczematous, thickened cutaneous lesion in the left perianal region. F-FDG PET/CT was performed, and neoplastic skin thickening with FDG uptake was seen at the left gluteal cleft. Hypermetabolic inguinal, retroperitoneal, and mediastinal lymph nodes, liver, and bone metastases were seen. Histopathology and immunohistochemistry of the perianal growth and left inguinal lymph node were positive for cytokeratin7 and gross cystic disease fluid protein and negative for cytokeratin 20 and CDX2, confirming the diagnosis of primary extramammary Paget disease with metastases.
一位 72 岁男性，病史为 8 个月瘙痒，于左侧肛周区域出现界限不清的、溃疡性、湿疹样、增厚的皮肤病变。行 F-FDG PET/CT 检查，于左侧臀裂处可见伴有 FDG 摄取的肿瘤性皮肤增厚。可见高代谢腹股沟、腹膜后和纵隔淋巴结、肝脏和骨转移。肛周生长物和左侧腹股沟淋巴结的组织病理学和免疫组织化学检查结果为细胞角蛋白 7 和大囊性病液蛋白阳性，细胞角蛋白 20 和 CDX2 阴性，证实了转移性原发性乳腺外派杰病的诊断。
