ISGlobal, Barcelona, Spain.
Pompeu Fabra University (UPF), Barcelona, Spain.
PLoS One. 2019 May 20;14(5):e0217157. doi: 10.1371/journal.pone.0217157. eCollection 2019.
Physical activity is key to improve the prognosis of chronic obstructive pulmonary disease (COPD). To help to tailor future interventions we aimed to identify the baseline characteristics of COPD patients which predict 12-month completion and response to a behavioral physical activity intervention.
This is a 12-month cohort study of the intervention arm of the Urban Training randomized controlled trial (NCT01897298), an intervention proven to be efficacious to increase physical activity. We considered baseline sociodemographic, interpersonal, environmental, clinical and psychological characteristics as potential determinants of completion and response. We defined completion as attending the 12-month study visit. Among completers, we defined response as increasing physical activity ≥1100 steps/day from baseline to 12 months, measured by accelerometer. We estimated the factors independently for completion and response using multivariable logistic regression models.
Of a total of 202 patients (m (SD) 69 (9) years, 84% male), 132 (65%) completed the study. Among those, 37 (28%) qualified as responders. Higher numbers of baseline steps/day (OR [95% CI] 1.11 [1.02-1.21] per increase of 1000 steps, p<0.05) and living with a partner (2.77 [1.41-5.48], p<0.01) were related to a higher probability of completion while more neighborhood vulnerability (0.70 [0.57-0.86] per increase of 0.1 units in urban vulnerability index, p<0.01) was related to a lower probability. Among the completers, working (3.14 [1.05-9.33], p<0.05) and having an endocrino-metabolic disease (4.36 [1.49-12.80], p<0.01) were related to a higher probability of response while unwillingness to follow the intervention (0.21 [0.05-0.98], p<0.05) was related to a lower probability.
This study found that 12-month completion of a behavioral physical activity intervention was generally determined by previous physical activity habits as well as interpersonal and environmental physical activity facilitators while response was related to diverse factors thought to modify the individual motivation to change to an active lifestyle.
体力活动是改善慢性阻塞性肺疾病（COPD）预后的关键。为了帮助定制未来的干预措施，我们旨在确定 COPD 患者的基线特征，这些特征可以预测行为体力活动干预的 12 个月完成情况和反应。
这是一项为期 12 个月的干预组队列研究，该研究是城市培训随机对照试验（NCT01897298）的干预部分，该试验已被证明能有效增加体力活动。我们认为基线社会人口统计学、人际、环境、临床和心理特征是完成和反应的潜在决定因素。我们将完成定义为参加 12 个月的研究访问。在完成者中，我们将反应定义为从基线到 12 个月时通过加速度计增加体力活动≥1100 步/天。我们使用多变量逻辑回归模型分别估计完成和反应的因素。
共有 202 名患者（m（SD）69（9）岁，84%为男性）完成了研究，其中 132 名（65%）完成了研究。其中，37 名（28%）符合应答者标准。基线每天步数更高（OR[95%CI]每增加 1000 步 1.11[1.02-1.21]，p<0.05）和与伴侣同住（2.77[1.41-5.48]，p<0.01）与更高的完成概率相关，而邻里脆弱性增加（0.70[0.57-0.86]每增加 0.1 个城市脆弱性指数单位，p<0.01）与较低的概率相关。在完成者中，工作（3.14[1.05-9.33]，p<0.05）和患有内分泌代谢疾病（4.36[1.49-12.80]，p<0.01）与更高的反应概率相关，而不愿意遵循干预措施（0.21[0.05-0.98]，p<0.05）与较低的概率相关。
这项研究发现，行为体力活动干预的 12 个月完成情况通常由以前的体力活动习惯以及人际和环境体力活动促进因素决定，而反应则与多种因素有关，这些因素被认为可以改变个体改变为积极生活方式的动机。
