既往季节流感疫苗的剩余效果。

Remaining Effect of Influenza Vaccines Received in Prior Seasons.

机构信息

Instituto de Salud Pública de Navarra - IdiSNA, Pamplona.

Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid.

出版信息

J Infect Dis. 2019 Aug 30;220(7):1136-1140. doi: 10.1093/infdis/jiz266.

DOI:10.1093/infdis/jiz266

PMID:31107953

Abstract

This study evaluates the remaining effect of influenza vaccines received in the 5 prior seasons. During 7 influenza seasons, 8933 patients were enrolled and 47% were confirmed for influenza. Compared with unvaccinated individuals in the current and 5 prior seasons, vaccination was protective when the last dose had been received in the current season (40% [95% confidence interval {CI}, 32%-47%]), and 1 (42% [95% CI, 27%-54%]), 2-3 (35% [95% CI, 16%-49%]), or 4-5 seasons (31% [95% CI, 4%-51%]) prior. This effect lasted for fewer seasons in the elderly and in patients with chronic conditions. On average, several recent prior doses were as protective as current-season vaccination.

摘要

这项研究评估了既往 5 个流感季节接种流感疫苗的剩余效果。在 7 个流感季节中，共纳入了 8933 名患者，其中 47%的患者确诊为流感。与当前和既往 5 个流感季节未接种疫苗的个体相比，当最近一次接种疫苗是在当前季节时（40%[95%置信区间{CI}，32%-47%]），1 次（42%[95%CI，27%-54%]）、2-3 次（35%[95%CI，16%-49%]）或 4-5 次（31%[95%CI，4%-51%]）前的疫苗接种具有保护作用。这种效果在老年人和慢性病患者中持续的时间较短。平均而言，最近的几次既往接种剂量与当前季节的疫苗接种一样具有保护作用。