Institute of Molecular Biology, University of Oregon, Eugene, Oregon; Institute of Neuroscience, University of Oregon, Eugene, Oregon; Department of Biology, University of Oregon, Eugene, Oregon.
Institute of Molecular Biology, University of Oregon, Eugene, Oregon; Department of Biology, University of Oregon, Eugene, Oregon.
Cell Mol Gastroenterol Hepatol. 2019;8(3):369-378. doi: 10.1016/j.jcmgh.2019.05.003. Epub 2019 May 18.
The intestinal epithelium does not function in isolation, but interacts with many components including the Enteric Nervous System (ENS). Understanding ENS and intestinal epithelium interactions requires multidisciplinary approaches to uncover cells involved, mechanisms used, and the ultimate influence on intestinal physiology. This review is intended to serve as a reference for epithelial biologists interested in studying these interactions. With this in mind, this review aims to summarize the basic anatomy of the epithelium and ENS, mechanisms by which they interact, and techniques used to study these interactions. We highlight in vitro, ex vivo and in vivo techniques. Additionally, ENS influence on epithelial proliferation and gene expression within stem and differentiated cells as well as gastrointestinal cancer are discussed.
肠上皮并非孤立地发挥作用，而是与包括肠神经系统（ENS）在内的许多成分相互作用。了解 ENS 和肠上皮的相互作用需要采用多学科方法来揭示涉及的细胞、所使用的机制以及对肠道生理学的最终影响。本综述旨在为有兴趣研究这些相互作用的上皮生物学家提供参考。有鉴于此，本综述旨在总结上皮和 ENS 的基本解剖结构、它们相互作用的机制以及用于研究这些相互作用的技术。我们重点介绍了体外、离体和体内技术。此外，还讨论了 ENS 对干细胞和分化细胞以及胃肠道癌中上皮增殖和基因表达的影响。
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