Huang Xinyu, Liu Yingying, Jiang Feng, Xin Laiyun, Wang Zhenyuan, Hua Zhen, Wang Cong, Zhang Lei, Yu Jie
The First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Shandong, China.
The Third Department of Cardiovascular Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong, China.
Front Microbiol. 2025 May 20;16:1530857. doi: 10.3389/fmicb.2025.1530857. eCollection 2025.
Hypertension is one of the most common cardiovascular diseases, with multiple underlying mechanisms. The gut microbiome, as one of the most important microbial communities in the human body, plays a significant role in the development of various diseases, including hypertension. While numerous studies have explored the relationship between gut microbiome and hypertension from different perspectives, there has been no bibliometric study in this field. Therefore, a bibliometric analysis is crucial for accurately assessing and summarizing the current research status. The analysis indicates that the number of publications in this field has steadily increased in recent years, with China and the United States leading in development. The journal Nutrients has the highest number of published papers, and Marques, Francine Z is a prominent figure with significant contributions and influence in this field. Co-occurrence and trend analysis suggest that the main research hotspots include the relationship between gut microbiome and hypertension, mechanisms by which gut microbiome promotes hypertension, and new therapeutic strategies targeting gut microbiome to improve hypertension. Future research trends may focus on expanding new metabolites or measurement techniques, building databases of human and animal gut microbiota and their metabolites, and developing new drugs targeting gut microbiota for hypertension. In summary, this study visually demonstrates the dynamic changes in research hotspots, revealing new patterns and focuses in the field, and aims to provide new insights for clinical work on hypertension.
高血压是最常见的心血管疾病之一,其潜在机制多种多样。肠道微生物群作为人体最重要的微生物群落之一,在包括高血压在内的各种疾病的发展中发挥着重要作用。虽然众多研究已从不同角度探讨了肠道微生物群与高血压之间的关系,但该领域尚未有文献计量学研究。因此,文献计量学分析对于准确评估和总结当前研究现状至关重要。分析表明,近年来该领域的出版物数量稳步增加,中国和美国在发展方面领先。《营养素》杂志发表的论文数量最多,弗朗辛·Z·马克斯是该领域有突出贡献和影响力的杰出人物。共现和趋势分析表明,主要研究热点包括肠道微生物群与高血压之间的关系、肠道微生物群促进高血压的机制以及针对肠道微生物群改善高血压的新治疗策略。未来研究趋势可能集中在扩展新的代谢产物或测量技术、建立人类和动物肠道微生物群及其代谢产物的数据库,以及开发针对肠道微生物群治疗高血压的新药。总之,本研究直观地展示了研究热点的动态变化,揭示了该领域的新模式和重点,旨在为高血压临床工作提供新的见解。