胃食管交界癌患者F-FDG PET/CT分子病理特征与代谢参数之间的相关性

The correlation between molecular pathological profiles and metabolic parameters of F-FDG PET/CT in patients with gastroesophageal junction cancer.

作者信息

Song Jinling, Li Zhongwu, Chen Puyun, Zhou Nina, Zhang Yan, Yang Zhi, Wang Xuejuan

机构信息

Department of Nuclear Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China.

Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, 100142, China.

出版信息

Abdom Radiol (NY). 2020 Feb;45(2):312-321. doi: 10.1007/s00261-019-02065-5.

DOI:10.1007/s00261-019-02065-5

PMID:31111196

Abstract

OBJECTIVE

The aim of this study was to evaluate PET/FDG metabolic parameters in locally advanced GEJC and correlate it with molecular pathological profiles.

METHODS

We retrospectively analyzed data from 66 patients with a histopathological diagnosis of GEJC who had undergone F-FDG PET/CT before surgical resection. Maximum standardized uptake (SUV), mean standardized uptake (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumor were measured and calculated using the region of interest (ROI) technique. The relationship between metabolic parameters and the Lauren's classification, histologic differentiation, Ki-67 staining and positivity for human epidermal growth factor receptor 2 (HER2), c-Met, and epidermal growth factor receptor (EGFR) were investigated through immunohistochemical (IHC) analyses.

RESULTS

Of the total 66 patients, significant differences were observed between intestinal and non-intestinal (mixed and diffuse) adenocarcinomas in SUV (8.23 ± 2.83 vs. 6.29 ± 2.41, P = 0.008), SUV (4.85 ± 1.47 vs. 3.93 ± 1.22, P = 0.017), MTV (24.96 cm vs. 8.90 cm; P = 0.004), and TLG (97.38 cm vs. 37.09 cm, P = 0.005) values. SUV, MTV, and TLG of moderately differentiated adenocarcinomas were significantly higher than those of the poorly differentiated ones. SUV was significantly higher in tissues with a higher Ki-67 index or in the c-MET-negative group (P = 0.045, P = 0.036). No significant correlation was found between metabolic parameters and the expression of HER2 or EGFR in GEJC.

CONCLUSION

F-FDG PET/CT may be useful for predicting the molecular pathological profiles of GEJC and for determining appropriate therapeutic strategy.

摘要

目的

本研究旨在评估局部晚期胃食管交界癌（GEJC）的PET/FDG代谢参数，并将其与分子病理特征相关联。

方法

我们回顾性分析了66例经组织病理学诊断为GEJC且在手术切除前接受了F-FDG PET/CT检查的患者的数据。使用感兴趣区（ROI）技术测量并计算原发性肿瘤的最大标准化摄取值（SUV）、平均标准化摄取值（SUV）、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）。通过免疫组织化学（IHC）分析研究代谢参数与劳伦分类、组织学分化、Ki-67染色以及人表皮生长因子受体2（HER2）、c-Met和表皮生长因子受体（EGFR）阳性之间的关系。

结果

在总共66例患者中，肠型腺癌与非肠型（混合型和弥漫型）腺癌在SUV（8.23±2.83对6.29±2.41，P = 0.008）、SUV（4.85±1.47对3.93±1.22，P = 0.017）、MTV（24.96 cm对8.90 cm；P = 0.004）和TLG（97.38 cm对37.09 cm，P = 0.005）值方面存在显著差异。中分化腺癌的SUV、MTV和TLG显著高于低分化腺癌。在Ki-67指数较高的组织或c-MET阴性组中，SUV显著更高（P = 0.045，P = 0.036）。在GEJC中，未发现代谢参数与HER2或EGFR表达之间存在显著相关性。