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[使用土瑞烯酮对前列腺癌进行保守治疗]

[Conservative therapy of prostate cancer using Turisteron].

作者信息

Schnorr D, Dörner G, Stahl F, Rohde W, Guddat H M

出版信息

Z Urol Nephrol. 1987 Mar;80(3):149-57.

PMID:3111122
Abstract

Turisteron is an orally highly effective depot estrogen (ethinylestradiol sulfonate) with relatively slight side effects. The treatment with Turisteron is very effective and is well tolerated by the patient. A strong antiandrogenic effect could be produced which had as its sequel a significant increase of the survival rates of patients with carcinoma of the prostate gland. The weekly dosage of 2 mg Turisteron led to a decrease of the biologically active, free testosterone to less than 2% compared with the initial value. The decrease of the total testosterone to castration values and the decrease of the free testosterone still significantly below values of castration are evidences for the strong antiandrogenic effect in exclusive estrogen treatment with Turisteron. From this conclusions relevant to practice were derived and finally therapy recommendation for the conservative treatment of the carcinoma of the prostate gland were given.

摘要

图瑞司酮是一种口服高效的长效雌激素(炔雌醇磺酸盐),副作用相对较小。使用图瑞司酮治疗非常有效,患者耐受性良好。它可产生强大的抗雄激素作用,其结果是前列腺癌患者的生存率显著提高。每周服用2毫克图瑞司酮可使生物活性游离睾酮与初始值相比降至不到2%。总睾酮降至去势水平,游离睾酮仍显著低于去势值,这证明了在单独使用图瑞司酮进行雌激素治疗时具有强大的抗雄激素作用。由此得出了与实践相关的结论,最终给出了前列腺癌保守治疗的治疗建议。

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