Rudolf K, Kunkel S, Rudolf H
Zentralbl Gynakol. 1987;109(8):501-9.
In 7 patients aged from 21 to 33 years (average age 24.6 years) with hyperprolactinemic galactorrhea a stimulation test with GnRH-TRH or arginine-GnRH-TRH was performed. The serum levels of LH, FSH, PRL, HGH, TSH and total thyroxine (T4) were determined by RIA, the thyroxine binding capacity (TBC) by radio agent assay. The free thyroxine index (FT4-I) was calculated. An adenoma of the pituitary gland was diagnosed in 3 patients by X-ray of sella turcica. In all patients there were disturbances of the menstrual cycle. Independent of the existence of an adenoma of the pituitary gland in all patients with high basal levels. PRL could not have been shown stimulated by TRH. On the other hand it could be shown that despite of high basal PRL-levels in serum there was a normal stimulation of the gonadotrophs in 5 patients. Out of one patient the stimulation of the thyreotropic cells of pituitary by TRH was normal, too, whereas there was no or an inadaquate stimulation of HGH by arginine in all patients.--T4, TBC and FT4-I showed no deviation from the normal range.
对7例年龄在21至33岁（平均年龄24.6岁）的高催乳素血症伴溢乳患者进行了促性腺激素释放激素-促甲状腺激素释放激素（GnRH-TRH）或精氨酸-促性腺激素释放激素-促甲状腺激素释放激素（arginine-GnRH-TRH）刺激试验。采用放射免疫分析法（RIA）测定血清促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PRL）、生长激素（HGH）、促甲状腺激素（TSH）和总甲状腺素（T4）水平，采用放射试剂分析法测定甲状腺素结合能力（TBC）。计算游离甲状腺素指数（FT4-I）。通过蝶鞍X线检查，3例患者诊断为垂体腺瘤。所有患者均有月经周期紊乱。在所有基础水平较高的患者中，无论是否存在垂体腺瘤，促甲状腺激素释放激素（TRH）均未显示能刺激催乳素升高。另一方面，结果显示，尽管血清基础催乳素水平较高，但5例患者的促性腺细胞刺激正常。1例患者促甲状腺激素释放激素对垂体促甲状腺细胞的刺激也正常，而所有患者中精氨酸对生长激素的刺激均无或不足。——T4、TBC和FT4-I均未偏离正常范围。
