Embryology Unit, Children's Medical Research Institute, The University of Sydney, Westmead, New South Wales, Australia.
Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Westmead, New South Wales, Australia.
Dev Growth Differ. 2019 Jun;61(5):327-336. doi: 10.1111/dgd.12609. Epub 2019 May 21.
Development of an embryo is driven by a series of molecular instructions that control the differentiation of tissue precursor cells and shape the tissues into major body parts. LIM homeobox 1 (LHX1) is a transcription factor that plays a major role in the development of the embryonic head of the mouse. Loss of LHX1 function disrupts the morphogenetic movement of head tissue precursors and impacts on the function of molecular factors in modulating the activity of the WNT signaling pathway. LHX1 acts with a transcription factor complex to regulate the transcription of target genes in multiple phases of development and in a range of embryonic tissues of the mouse and Xenopus. Determining the interacting factors and transcriptional targets of LHX1 will be key to unraveling the ensemble of factors involved in head development and building a head gene regulatory network.
胚胎的发育是由一系列分子指令驱动的，这些指令控制组织前体细胞的分化，并将组织塑造成主要身体部位。LIM 同源盒 1（LHX1）是一种转录因子，在小鼠胚胎头部的发育中起着重要作用。LHX1 功能的丧失会破坏头部组织前体的形态发生运动，并影响调节 WNT 信号通路活性的分子因子的功能。LHX1 与转录因子复合物一起作用，调节小鼠和非洲爪蟾的多个发育阶段和一系列胚胎组织中靶基因的转录。确定 LHX1 的相互作用因子和转录靶标将是揭示参与头部发育的因子组合并构建头部基因调控网络的关键。
