Sun Wei, Huang Jin-Qiang, Chen Lin, Wen Wei-Ping
Department of Otorhinolaryngology Head and Neck Surgery and Guangzhou Key Laboratory of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Department of Otorhinolaryngology Head and Neck Surgery and Guangzhou Key Laboratory of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China,
ORL J Otorhinolaryngol Relat Spec. 2019;81(2-3):82-91. doi: 10.1159/000499474. Epub 2019 May 21.
Induction chemotherapy (ICT) has become an initial treatment for late-stage hypopharyngeal squamous cell carcinoma (SCC); however, there are no data regarding ICT sensitivity for this population.
This study investigated the predictive value of various inflammation markers for ICT responses in hypopharyngeal SCC.
The data from 72 patients who received initial ICT treatment were obtained and associations between pretreatment inflammation markers and overall responses to ICT were calculated.
According to receiver operating characteristic curves, pretreatment lymphocyte count (PLC), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) achieved diagnostic accuracy for overall responses to ICT. These indicators were classified into two groups according to their cut-off values. Overall response rates were significantly higher in the low PLC (p < 0.01), high NLR (p = 0.035), and high PLR (p = 0.012) groups.
Our results showed that low PLC, high NLR, and high PLR are predictors of positive responses to ICT in hypopharyngeal SCC patients.
诱导化疗（ICT）已成为晚期下咽鳞状细胞癌（SCC）的初始治疗方法；然而，关于该人群对ICT的敏感性尚无数据。
本研究调查了各种炎症标志物对下咽SCC患者ICT反应的预测价值。
获取了72例接受初始ICT治疗患者的数据，并计算了治疗前炎症标志物与ICT总体反应之间的关联。
根据受试者工作特征曲线，治疗前淋巴细胞计数（PLC）、中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）对ICT总体反应具有诊断准确性。这些指标根据其临界值分为两组。低PLC组（p < 0.01）、高NLR组（p = 0.035）和高PLR组（p = 0.012）的总体反应率显著更高。
我们的结果表明，低PLC、高NLR和高PLR是下咽SCC患者对ICT产生阳性反应的预测指标。
