Szymanik-Grzelak Hanna, Daniel Maria Urszula, Skrzypczyk Piotr, Kotuła Iwona, Pańczyk-Tomaszewska Małgorzata
Department of Paediatric and Nephrology, The Medical University of Warsaw, Warsaw, Poland.
Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, The Medical University of Warsaw,Warsaw, Poland.
Cent Eur J Immunol. 2019;44(1):38-44. doi: 10.5114/ceji.2019.84013. Epub 2019 Apr 15.
The position of copeptin (C-terminal fragment of antidiuretin propeptide) as a marker of primary monosymptomatic nocturnal enuresis (PMNE) is under debate, and there are no data on the relation between copeptin and clinical and biochemical parameters in these patients. Aim of the study was to assess the level of serum copeptin in children with PMNE and to look for a relation between copeptin and selected clinical and biochemical parameters in these children.
Twenty-five children recruited for the trial fulfilled the following criteria: clinical diagnosis of PMNE, age 5-15 years, normal creatinine level, normal ultrasonographic image of kidneys and urinary tract. The following parameters were evaluated: serum copeptin, creatinine, sodium, potassium, hematocrit and urine specific gravity. Twenty healthy children were included in the control group.
Children from study and control groups did not differ in serum copeptin, sex, age creatinine, sodium, hematocrit and specific gravity. Serum potassium level remained normal in subjects but was significantly higher in the study group. In children with PMNE we found no relation between serum copeptin level and sex, kidney function, sodium, and urinary specific gravity. We found a negative correlation between copeptin and bladder capacity and trends towards positive relations between copeptin and age, as well as hemoglobin. In the subgroup of children with normal bladder capacity a trend towards a positive correlation between copeptin and potassium was found.
Copeptin may be a marker of hydration status in children with PMNE. The relation between potassium and copeptin levels and the clinical significance of the relation require further studies.
copeptin（抗利尿激素前体肽的C末端片段）作为原发性单症状性夜间遗尿症（PMNE）标志物的地位存在争议，且尚无关于这些患者中copeptin与临床及生化参数之间关系的数据。本研究的目的是评估PMNE患儿的血清copeptin水平，并探寻这些患儿中copeptin与选定临床及生化参数之间的关系。
招募的25名参与试验的儿童符合以下标准：PMNE临床诊断，年龄5至15岁，肌酐水平正常，肾脏及尿路超声图像正常。评估以下参数：血清copeptin、肌酐、钠、钾、血细胞比容和尿比重。对照组纳入20名健康儿童。
研究组和对照组儿童在血清copeptin、性别、年龄、肌酐、钠、血细胞比容和比重方面无差异。受试者血清钾水平保持正常，但研究组显著更高。在PMNE患儿中，我们未发现血清copeptin水平与性别、肾功能、钠及尿比重之间存在关联。我们发现copeptin与膀胱容量呈负相关，且copeptin与年龄以及血红蛋白之间存在正相关趋势。在膀胱容量正常的儿童亚组中，发现copeptin与钾之间存在正相关趋势。
copeptin可能是PMNE患儿水合状态的标志物。钾与copeptin水平之间的关系及其临床意义需要进一步研究。
