Urology Department, Faculty of Medicine for Girls, AlAzhar University, Cairo, Egypt.
Clinical Pathology Department, Faculty of Medicine for Girls, AlAzhar University, Cairo, Egypt.
Int J Urol. 2023 Jun;30(6):560-565. doi: 10.1111/iju.15172. Epub 2023 Feb 28.
To determine the utility of serum copeptin and urinary aquaporin-2 (AQP2) levels in diagnosing primary monosymptomatic nocturnal enuresis (PMNE) in children.
This study comprised 58 children (30 males and 28 females), aged 9.7 (±2.9) years with PMNE enuresis. Another 29 children (16 males and 13 females) aged 10.2 (±3.3) without nocturnal enuresis (NE) were recruited as a control group. History taking, clinical examination, and assessment of serum copeptin (blood) and AQP-2 levels (urine) were performed in all participants.
Serum levels of copeptin, potassium and urinary AQP-2, and urine creatinine levels were lower in the PMNE group compared to the control group (p < 0.001 for all). No significant differences in body mass index, urine specific gravity, serum sodium, serum creatinine, or estimated glomerular filtration rate were observed between groups. This study evaluated both serum copeptin and AQP-2 levels in healthy and enuretic children.
In this study, serum levels of copeptin (blood) and AQP2 (urine) were significantly lower in enuretic patients compared to healthy controls. Further, the measurement of urinary AQP-2 levels is more practical than serum copeptin levels due to lower invasiveness.
确定血清 copeptin 和尿 aquaporin-2（AQP2）水平在诊断儿童原发性单症状性夜间遗尿症（PMNE）中的应用价值。
本研究纳入 58 例年龄为 9.7（±2.9）岁的 PMNE 遗尿症患儿（30 名男性，28 名女性），另招募 29 例年龄为 10.2（±3.3）岁、无夜间遗尿症（NE）的儿童作为对照组。所有参与者均进行病史采集、临床检查和血清 copeptin（血液）和 AQP-2 水平（尿液）评估。
与对照组相比，PMNE 组血清 copeptin、钾和尿 AQP-2 以及尿肌酐水平均较低（p<0.001）。两组间的体重指数、尿比重、血清钠、血清肌酐或估算肾小球滤过率无显著差异。本研究评估了健康和遗尿儿童的血清 copeptin 和 AQP-2 水平。
在本研究中，与健康对照组相比，遗尿症患者的血清 copeptin（血液）和 AQP2（尿液）水平显著降低。此外，由于侵袭性较低，测量尿 AQP-2 水平比测量血清 copeptin 水平更实用。
