炎症在骨髓增殖性肿瘤中的关键作用：疾病起始、进展和症状的推动者。
Key Role of Inflammation in Myeloproliferative Neoplasms: Instigator of Disease Initiation, Progression. and Symptoms.
机构信息
Department of Biological Chemistry, University of California Irvine, 839 Medical Sciences Rd, Sprague Hall 126, Irvine, CA, 92617, USA.
Division of Hematology/Oncology, Department of Medicine, University of California Irvine, 839 Medical Sciences Rd, Sprague Hall 126, Irvine, CA, 92617, USA.
出版信息
Curr Hematol Malig Rep. 2019 Jun;14(3):145-153. doi: 10.1007/s11899-019-00508-w.
Abstract
PURPOSE OF REVIEW
Chronic inflammation is a characteristic feature of myeloproliferative neoplasm (MPN) and impacts many aspects of the disease including initiation, progression, and symptomatology.
RECENT FINDINGS
The chronic inflammatory state of MPN results from disruption of immune signaling pathways leading to overproduction of inflammatory cytokines by both the neoplastic clones and bystander immune cells. This chronic inflammation may allow for the neoplastic clone to gain a selective advantage. The symptomatic burden felt by MPN patients may be a result of the chronic inflammation associated with MPN, as several cytokines have been linked with different symptoms. Pharmacologic as well as nonpharmacologic treatments of the inflammatory component of this disease may lead to decreased symptomatic burden, prevention of disease progression, and improvement in overall disease trajectory. Inflammation plays a key role in the pathogenesis of MPN and represents an important therapeutic target.
摘要
目的综述
慢性炎症是骨髓增殖性肿瘤（MPN）的特征之一，影响疾病的许多方面，包括发病、进展和症状学。
最新发现
MPN 的慢性炎症状态源于免疫信号通路的破坏，导致肿瘤克隆和旁观者免疫细胞过度产生炎性细胞因子。这种慢性炎症可能使肿瘤克隆获得选择性优势。MPN 患者的症状负担可能是与 MPN 相关的慢性炎症的结果，因为几种细胞因子与不同的症状有关。这种疾病炎症成分的药物和非药物治疗可能会减轻症状负担，预防疾病进展，并改善整体疾病轨迹。炎症在 MPN 的发病机制中起关键作用，是一个重要的治疗靶点。
相似文献
1
Key Role of Inflammation in Myeloproliferative Neoplasms: Instigator of Disease Initiation, Progression. and Symptoms.炎症在骨髓增殖性肿瘤中的关键作用：疾病起始、进展和症状的推动者。
Curr Hematol Malig Rep. 2019 Jun;14(3):145-153. doi: 10.1007/s11899-019-00508-w.
2
Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm.炎症作为骨髓增殖性肿瘤克隆进化的驱动因素
Mediators Inflamm. 2015;2015:606819. doi: 10.1155/2015/606819. Epub 2015 Oct 11.
3
Fecal Microbial Community Composition in Myeloproliferative Neoplasm Patients Is Associated with an Inflammatory State.骨髓增殖性肿瘤患者的粪便微生物群落组成与炎症状态有关。
Microbiol Spectr. 2022 Jun 29;10(3):e0003222. doi: 10.1128/spectrum.00032-22. Epub 2022 Apr 27.
4
Inflammation and myeloproliferative neoplasms.炎症和骨髓增殖性肿瘤。
J Autoimmun. 2017 Dec;85:58-63. doi: 10.1016/j.jaut.2017.06.010. Epub 2017 Jun 30.
5
The Rationale for Immunotherapy in Myeloproliferative Neoplasms.骨髓增殖性肿瘤免疫治疗的理论依据。
Curr Hematol Malig Rep. 2019 Aug;14(4):310-327. doi: 10.1007/s11899-019-00527-7.
6
Role of inflammation in the biology of myeloproliferative neoplasms.炎症在骨髓增殖性肿瘤生物学中的作用。
Blood Rev. 2020 Jul;42:100711. doi: 10.1016/j.blre.2020.100711. Epub 2020 May 30.
7
Platelets as Mediators of Thromboinflammation in Chronic Myeloproliferative Neoplasms.血小板在慢性骨髓增殖性肿瘤中的血栓炎症中介作用。
Front Immunol. 2019 Jun 14;10:1373. doi: 10.3389/fimmu.2019.01373. eCollection 2019.
8
Impact of Host, Lifestyle and Environmental Factors in the Pathogenesis of MPN.宿主、生活方式和环境因素在骨髓增殖性肿瘤发病机制中的作用
Cancers (Basel). 2020 Jul 24;12(8):2038. doi: 10.3390/cancers12082038.
9
The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence.NUTRIENT 试验（骨髓增殖性肿瘤患者的营养干预）：一项随机 I 期探索性研究的结果，旨在评估可行性和依从性。
Cancer Res Commun. 2024 Mar 5;4(3):660-670. doi: 10.1158/2767-9764.CRC-23-0380.
10
Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression.慢性期以及疾病进展过程中骨髓增殖性肿瘤和骨髓增生异常/骨髓增殖性肿瘤的基因组畸变。
Int J Lab Hematol. 2015 Apr;37(2):181-9. doi: 10.1111/ijlh.12257. Epub 2014 May 21.
引用本文的文献
1
Management of Myeloproliferative Neoplasms: An Integrative Approach.骨髓增殖性肿瘤的管理：一种综合方法。
J Clin Med. 2025 Jul 17;14(14):5080. doi: 10.3390/jcm14145080.
2
Extreme Thrombocytosis in Patients with Overt Myelofibrosis and Its Clinical Associations.明显骨髓纤维化患者的极端血小板增多症及其临床关联
Cancers (Basel). 2025 Apr 22;17(9):1390. doi: 10.3390/cancers17091390.
3
Prognostic significance of baseline serum ferritin in newly diagnosed multiple myeloma cases: A retrospective study from southern India.新诊断多发性骨髓瘤患者基线血清铁蛋白的预后意义：一项来自印度南部的回顾性研究。
Indian J Med Res. 2025 Mar;161(3):306-314. doi: 10.25259/IJMR_1065_2024.
4
Intersecting Pathologies: Polycythemia Vera and Recurrent Infections in an Elderly Patient.交叉病理：一名老年患者的真性红细胞增多症和反复感染
Cureus. 2025 Mar 4;17(3):e80029. doi: 10.7759/cureus.80029. eCollection 2025 Mar.
5
Suppressed activation of the IRF7 and TLR9 by JAK2V617F gold nanoparticles.JAK2V617F金纳米颗粒抑制IRF7和TLR9的激活。
Immunogenetics. 2025 Feb 28;77(1):16. doi: 10.1007/s00251-025-01374-y.
6
High Levels of C5a Are Associated With Reduced Macular Sensitivity in Patients With Myeloproliferative Neoplasms.高水平的C5a与骨髓增殖性肿瘤患者黄斑敏感性降低有关。
Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):41. doi: 10.1167/iovs.66.2.41.
7
JAK2V617F-dependent down regulation of SHP-1 expression participates in the selection of myeloproliferative neoplasm cells in the presence of TGF-β.JAK2V617F 依赖性下调 SHP-1 表达参与 TGF-β 存在时骨髓增殖性肿瘤细胞的选择。
J Cell Mol Med. 2024 Oct;28(20):e70138. doi: 10.1111/jcmm.70138.
8
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as novel prognostic biomarkers in BCR-ABL negative myeloproliferative neoplasms.中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值作为 BCR-ABL 阴性骨髓增殖性肿瘤的新型预后生物标志物。
Ann Hematol. 2024 Nov;103(11):4545-4556. doi: 10.1007/s00277-024-06023-0. Epub 2024 Sep 27.
9
Metformin for MPN: teaching an old drug new tricks.二甲双胍用于骨髓增殖性肿瘤：让老药发挥新作用
Blood Adv. 2024 Aug 27;8(16):4476-4477. doi: 10.1182/bloodadvances.2024013429.
10
The Systemic Inflammation Index: A New Candidate Minor Criterion in the Diagnosis of Polycythemia Vera.全身炎症指数：真性红细胞增多症诊断中一个新的候选次要标准
J Pers Med. 2024 Apr 29;14(5):471. doi: 10.3390/jpm14050471.
本文引用的文献
1
Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NFκB signaling.骨髓纤维化中的细胞因子产生表现出对 JAK-STAT、MAP 激酶和 NFκB 信号的不同反应性。
Leukemia. 2019 Aug;33(8):1978-1995. doi: 10.1038/s41375-019-0379-y. Epub 2019 Feb 4.
2
Defective negative regulation of Toll-like receptor signaling leads to excessive TNF-α in myeloproliferative neoplasm.Toll 样受体信号转导的缺陷负调控导致骨髓增殖性肿瘤中 TNF-α 过多。
Blood Adv. 2019 Jan 22;3(2):122-131. doi: 10.1182/bloodadvances.2018026450.
3
Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression.微生物群驱动的白细胞介素-17 产生细胞和嗜酸性粒细胞协同作用加速多发性骨髓瘤的进展。
Nat Commun. 2018 Dec 3;9(1):4832. doi: 10.1038/s41467-018-07305-8.
4
Clinical consequences of clonal hematopoiesis of indeterminate potential.不确定潜能的克隆性造血的临床后果。
Blood Adv. 2018 Nov 27;2(22):3404-3410. doi: 10.1182/bloodadvances.2018020222.
5
Perceptions of Myeloproliferative Neoplasm Patients Participating in an Online Yoga Intervention: A Qualitative Study.参与在线瑜伽干预的骨髓增殖性肿瘤患者的认知：一项定性研究
Integr Cancer Ther. 2018 Dec;17(4):1150-1162. doi: 10.1177/1534735418808595. Epub 2018 Oct 23.
6
Smoking is associated with increased risk of myeloproliferative neoplasms: A general population-based cohort study.吸烟与骨髓增生性肿瘤风险增加相关：基于一般人群的队列研究。
Cancer Med. 2018 Nov;7(11):5796-5802. doi: 10.1002/cam4.1815. Epub 2018 Oct 14.
7
Characteristics of myeloproliferative neoplasms in patients exposed to ionizing radiation following the Chernobyl nuclear accident.切尔诺贝利核事故后接受电离辐射的患者的骨髓增殖性肿瘤特征。
Am J Hematol. 2019 Jan;94(1):62-73. doi: 10.1002/ajh.25307. Epub 2018 Oct 31.
8
Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts.补充特级初榨橄榄油或坚果的地中海饮食对心血管疾病的一级预防
N Engl J Med. 2018 Jun 21;378(25):e34. doi: 10.1056/NEJMoa1800389. Epub 2018 Jun 13.
9
Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.致癌激活和炎症信号的双重靶向增强骨髓增殖性肿瘤的治疗效果。
Cancer Cell. 2018 Apr 9;33(4):785-787. doi: 10.1016/j.ccell.2018.03.024.
10
Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer.低依从西式饮食模式和高依从地中海饮食模式可预防结直肠癌。
Eur J Nutr. 2019 Jun;58(4):1495-1505. doi: 10.1007/s00394-018-1674-5. Epub 2018 Mar 26.
Zotero 插件