Vogel Kathleen M, Ouagrham-Gormley Sonia Ben
University of Maryland,
George Mason University.
Politics Life Sci. 2018 Dec 4;37(2):203-219. doi: 10.1017/pls.2018.21.
This article discusses the contingencies and complexities of CRISPR. It outlines key problems regarding off-target effects and replication of experimental work that are important to consider in light of CRISPR's touted ease of use and diffusion. In light of literature on the sociotechnical dimensions of the life sciences and biotechnology and literature on former bioweapons programs, this article argues that we need more detailed empirical case studies of the social and technical factors shaping CRISPR and related gene-editing techniques in order to better understand how they may be different from other advances in biotechnology-or whether similar features remain. This information will be critical to better inform intelligence practitioners and policymakers about the security implications of new gene-editing techniques.
本文讨论了CRISPR的意外情况和复杂性。它概述了脱靶效应和实验工作重复性等关键问题，鉴于CRISPR被吹捧的易用性和广泛传播，这些问题很重要，值得考虑。鉴于关于生命科学和生物技术的社会技术层面的文献以及关于以往生物武器计划的文献，本文认为，我们需要对塑造CRISPR及相关基因编辑技术的社会和技术因素进行更详细的实证案例研究，以便更好地理解它们与生物技术的其他进展有何不同，或者是否存在类似特征。这些信息对于让情报从业人员和政策制定者更好地了解新基因编辑技术的安全影响至关重要。
