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撒哈拉以南非洲的 CRISPR:应用与教育。

CRISPR in Sub-Saharan Africa: Applications and Education.

机构信息

Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697-4500, USA; Department of Animal and Environmental Biology, Federal University Oye-Ekiti, 371010 Ekiti State, Nigeria; Laboratory website: http://sites.uci.edu/jameslab.

Department of Animal and Environmental Biology, Federal University Oye-Ekiti, 371010 Ekiti State, Nigeria.

出版信息

Trends Biotechnol. 2019 Mar;37(3):234-237. doi: 10.1016/j.tibtech.2018.07.012. Epub 2018 Aug 9.

DOI:10.1016/j.tibtech.2018.07.012
PMID:30100229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6378648/
Abstract

Clustered regularly interspaced short palindromic repeats (CRISPR) technology has enabled genetic engineering feats previously considered impracticable, offering great hopes for solutions to problems facing society. We consider it timely to highlight how CRISPR can benefit public health, medicine, and agriculture in sub-Saharan Africa (SSA) and offer recommendations for successful implementation.

摘要

成簇规律间隔短回文重复序列(CRISPR)技术使以前被认为不可行的基因工程壮举成为可能,为解决社会面临的问题带来了巨大的希望。我们认为,现在是时候强调 CRISPR 如何有益于撒哈拉以南非洲(SSA)的公共卫生、医学和农业,并为成功实施提供建议。

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Population modification of Anopheline species to control malaria transmission.通过改变按蚊种类来控制疟疾传播。
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Genetic diversity of the African malaria vector Anopheles gambiae.非洲疟疾媒介冈比亚按蚊的遗传多样性。
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Efficient CRISPR/Cas9 Genome Editing of in Cassava.木薯中高效的CRISPR/Cas9基因组编辑
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Correction of a pathogenic gene mutation in human embryos.人类胚胎中致病基因突变的纠正。
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Results from the Workshop "Problem Formulation for the Use of Gene Drive in Mosquitoes".“蚊子基因驱动应用的问题阐述”研讨会结果
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