作为测试植物药生物活性的模式系统：以 L. Schrad. 有机提取物为例。
as a Model System to Test the Biological Activity of Botanicals: An Example on L. Schrad. Organic Extracts.
机构信息
Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Laboratory of Chemical, Galenic and Pharmacological Development of Drugs, Faculty of Pharmacy of Monastir, University of Monastir, 5000 Monastir, Tunisia.
出版信息
Toxins (Basel). 2019 May 22;11(5):286. doi: 10.3390/toxins11050286.
L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin. Many pharmacological properties (anti-inflammatory, anti-diabetic, analgesic, anti-epileptic) are ascribed to different organs of this plant; extracts and derivatives of are used in folk Berber medicine for the treatment of numerous diseases-such as rheumatism arthritis, hypertension bronchitis, mastitis, and even cancer. Clinical studies aimed at confirming the chemical and biological bases of pharmacological activity assigned to many plant/herb extracts used in folk medicine often rely on results obtained from laboratory preliminary tests. We investigated the biological activity of some stem, leaf, and root extracts on the mycotoxigenic and phytopathogenic fungus , testing a possible correlation between the inhibitory effect on aflatoxin biosynthesis, the phytochemical composition of extracts, and their in vitro antioxidant capacities.
L. Schrader 是旋花科一年生植物，广泛分布在地中海盆地沙漠地区。该植物的不同器官具有多种药理学特性（抗炎、抗糖尿病、镇痛、抗癫痫）；其提取物和衍生物在柏柏尔民间医学中用于治疗许多疾病，如风湿性关节炎、高血压、支气管炎、乳腺炎，甚至癌症。旨在证实用于民间医学的许多植物/草药提取物的化学和生物学基础的临床研究，通常依赖于从实验室初步测试中获得的结果。我们研究了旋花科一些茎、叶和根提取物对产毒真菌和植物病原菌的生物活性，测试了抑制黄曲霉毒素生物合成、提取物的植物化学成分及其体外抗氧化能力之间的可能相关性。
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