Department of Pediatrics, Tokushima University, Tokushima, Japan.
Department of Pediatrics, Tokushima University, Tokushima, Japan.
Ultrasound Med Biol. 2019 Aug;45(8):1999-2009. doi: 10.1016/j.ultrasmedbio.2019.04.021. Epub 2019 May 20.
We hypothesized that the kinematic model-based parameters obtained from the transtricuspid E-wave would be useful for evaluating the right ventricular diastolic property in pediatric pulmonary arterial hypertension (PAH) patients. The model was parametrized by stiffness/elastic recoil k, relaxation/damping c and load x. These parameters were determined as the solution of m⋅dx/dt + c⋅dx/dt + kx = 0, which is based on the theory that the E-wave contour is determined by the interplay of stiffness/restoring force, damping/relaxation force and load. The PAH group had a significantly higher k and c compared with the control group (182.5 ± 72.4 g/s vs. 135.7 ± 49.5 g/s, p = 0.0232, and 21.9 ± 6.5 g/s vs. 10.6 ± 5.2 g/s, p <0.0001, respectively). These results indicate that in the PAH group, the right ventricle had higher stiffness/elastic recoil and inferior cross-bridge relaxation. The present findings indicate the feasibility and utility of using kinematic model parameters to assess right ventricular diastolic function.
我们假设基于三尖瓣 E 波的运动学模型参数可用于评估小儿肺动脉高压（PAH）患者的右心室舒张功能。该模型由刚度/弹性回弹 k、松弛/阻尼 c 和负载 x 参数化。这些参数是通过 m⋅dx/dt + c⋅dx/dt + kx = 0 求解得到的，这是基于 E 波轮廓由刚度/恢复力、阻尼/松弛力和负载相互作用决定的理论。PAH 组的 k 和 c 显著高于对照组（182.5 ± 72.4 g/s 比 135.7 ± 49.5 g/s，p = 0.0232，21.9 ± 6.5 g/s 比 10.6 ± 5.2 g/s，p <0.0001）。这些结果表明，在 PAH 组中，右心室具有更高的刚度/弹性回弹和较差的横桥松弛。这些发现表明使用运动学模型参数评估右心室舒张功能的可行性和实用性。
