Newcom S R, Kadin M E
Cancer. 1979 Feb;43(2):622-6. doi: 10.1002/1097-0142(197902)43:2<622::aid-cncr2820430232>3.0.co;2-q.
The prognosis of acute lymphoblastic leukemia is affected adversely by T-cell markers on the malignant lymphoblasts. Direct involvement of the thymus has been assumed because of frequent mediastinal enlargement in these patients and the important role of the thymus in certain mouse leukemias. We report here an adult with T-cell leukemia and mediastinal enlargement who had physiologic involution of the thymus. The possible role of diphenylhydantoin in the pathogenesis of this disease is reviewed. The possible usefulness of Nu/Nu mouse xenografting for the study of this lethal disorder is discussed.
急性淋巴细胞白血病的预后会受到恶性淋巴母细胞上T细胞标志物的不利影响。由于这些患者中纵隔肿大频繁，且胸腺在某些小鼠白血病中具有重要作用，因此推测胸腺有直接受累情况。我们在此报告一名患有T细胞白血病并伴有纵隔肿大的成年人，其胸腺发生了生理性退化。本文回顾了苯妥英在该疾病发病机制中的可能作用。讨论了Nu/Nu小鼠异种移植在研究这种致命疾病方面的可能用途。
