Hann H W, London W T, Evans A E
Cancer. 1977 May;39(5):2001-3. doi: 10.1002/1097-0142(197705)39:5<2001::aid-cncr2820390516>3.0.co;2-n.
In previous reports, children with acute lymphoblastic leukemia (ALL), who presented with T-cell markers on their lymphoblasts (T-lymphoblasts), have been predominantly older boys often with a mediastinal mass. These children are thought to constitute a subgroup of childhood ALL that has the poorest prognosis. Here, we report five girls with ALL, who presented with T-lymphoblasts but without a mediastinal mass. All responded well to chemotherapy and three of five are in maintained remission 21-33 months after diagnosis. The fourth patient died while in remission of causes other than leukemia and the fifth relapsed and died of infection two years after diagnosis. These observations suggest that girls with T-lymphoblasts may not have an adverse prognosis.
在以往的报告中，患有急性淋巴细胞白血病（ALL）且其淋巴母细胞（T淋巴母细胞）呈现T细胞标志物的儿童，主要是年龄较大的男孩，且常伴有纵隔肿块。这些儿童被认为构成了儿童ALL中预后最差的一个亚组。在此，我们报告5例患有ALL且呈现T淋巴母细胞但无纵隔肿块的女孩。所有患儿对化疗反应良好，5例中有3例在诊断后21 - 33个月处于持续缓解状态。第四例患者在缓解期因白血病以外的原因死亡，第五例在诊断两年后复发并死于感染。这些观察结果表明，患有T淋巴母细胞的女孩可能没有不良预后。
