Department of Environmental and Occupational Health Sciences , University of Washington , Seattle , Washington 98109 , United States.
Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine , University of Washington , Seattle , Washington 98109 , United States.
Chem Res Toxicol. 2019 Jun 17;32(6):952-968. doi: 10.1021/acs.chemrestox.8b00234. Epub 2019 Jun 5.
Silver nanoparticles (AgNP) are used in multiple applications but primarily in the manufacturing of antimicrobial products. AgNP toxicity in the respiratory system is well characterized, but few in vitro or in vivo studies have evaluated the effects of interactions between host genetic and acquired factors or gene × environment interactions (G × E) on AgNP toxicity in the respiratory system. The primary goal of this article is to review host genetic and acquired factors identified across in vitro and in vivo studies and prioritize those necessary for defining exposure limits to protect all populations. The impact of these exposures and the work being done to address the current limited protections are also discussed. Future research on G × E effects on AgNP toxicity is warranted and will assist with informing regulatory or recommended exposure limits that enforce special protections for all populations to AgNP exposures in occupational settings.
银纳米粒子（AgNP）被广泛应用于多种领域，但主要应用于抗菌产品的制造。AgNP 在呼吸系统中的毒性已经得到了充分的研究，但很少有体外或体内研究评估宿主遗传和获得性因素之间的相互作用或基因×环境相互作用（G×E）对 AgNP 在呼吸系统中毒性的影响。本文的主要目标是综述已在体外和体内研究中确定的宿主遗传和获得性因素，并优先考虑那些对确定暴露限值以保护所有人群所必需的因素。还讨论了这些暴露的影响以及为解决当前有限保护措施所做的工作。关于 G×E 对 AgNP 毒性影响的未来研究是必要的，这将有助于为职业环境中 AgNP 暴露的所有人群制定监管或推荐的暴露限值提供信息，以实施特殊保护。
