Hunt S P, Pini A, Evan G
Nature. 1987;328(6131):632-4. doi: 10.1038/328632a0.
It has been suggested that the proto-oncogenes c-fos and c-myc participate in the control of genetic events which lead to the establishment of prolonged functional changes in neurons. Expression of c-fos and c-myc are among the earliest genetic events induced in cultured fibroblast and phaeochromocytoma cell lines by various stimuli including growth factors, peptides and the intracellular second messengers diacylglycerol, cAMP and Ca2+. We report here that physiological stimulation of rat primary sensory neurons causes the expression of c-fos-protein-like immunoreactivity in nuclei of postsynaptic neurons of the dorsal horn of the spinal cord. Activation of small-diameter cutaneous sensory afferents by noxious heat or chemical stimuli results in the rapid appearance of c-fos-protein-like immunoreactivity in the superficial layers of the dorsal horn. However, activation of low-threshold cutaneous afferents results in fewer labelled cells with a different laminar distribution. No c-fos induction was seen in the dorsal root ganglia, gracile nucleus or ventral horn. Thus, synaptic transmission may induce rapid changes in gene expression in certain postsynaptic neurons.
有人提出原癌基因c-fos和c-myc参与了对遗传事件的控制，这些遗传事件会导致神经元产生长期的功能变化。c-fos和c-myc的表达是培养的成纤维细胞和嗜铬细胞瘤细胞系中最早由各种刺激诱导的遗传事件之一，这些刺激包括生长因子、肽以及细胞内第二信使二酰基甘油、cAMP和Ca2+。我们在此报告，对大鼠初级感觉神经元的生理刺激会导致脊髓背角突触后神经元细胞核中出现c-fos蛋白样免疫反应性。有害热或化学刺激激活小直径皮肤感觉传入神经会导致背角浅层迅速出现c-fos蛋白样免疫反应性。然而，低阈值皮肤传入神经的激活导致标记细胞较少，且层状分布不同。在背根神经节、薄束核或腹角未观察到c-fos诱导。因此，突触传递可能会在某些突触后神经元中诱导基因表达的快速变化。
