1 College of Medicine, University of Nebraska Medical Center, Omaha, USA.
2 Department of Rheumatology, University of Nebraska Medical Center, Omaha, USA.
Lupus. 2019 Jul;28(8):1013-1016. doi: 10.1177/0961203319847274. Epub 2019 May 24.
Livedoid vasculopathy (LV) is a small vessel occlusive disease that can present with a painful purpuric eruption. Predominantly affecting young women, LV has been associated with hypercoagulable states and antiphospholipid syndrome. We present an unusual case of LV occurring in the setting of acute kidney injury secondary to lupus nephritis. It is important to differentiate LV from vasculitis as the treatment recommendation centers on anticoagulation therapy rather than immunosuppression. Additionally, antiphospholipid syndrome should be ruled out in cases of systemic lupus erythematosus with LV due to risk of thrombotic events.
皮肤白细胞破碎性血管炎(LV)是一种小血管闭塞性疾病,可表现为疼痛性紫癜性疹。LV 主要影响年轻女性,与高凝状态和抗磷脂综合征有关。我们报告了一例狼疮性肾炎继发急性肾损伤时发生的不常见 LV 病例。重要的是要将 LV 与血管炎区分开来,因为治疗建议集中在抗凝治疗上,而不是免疫抑制治疗上。此外,由于存在血栓形成事件的风险,对于伴有 LV 的系统性红斑狼疮,应排除抗磷脂综合征。