Kozlovskaia N L, Kabaenkova G S, Varshavskiĭ V A, Shvetsov M Iu
Klin Med (Mosk). 1995;73(3):93-6.
A case of rapidly progressive nephritis is reported in a female patient having systemic lupus erythematosus (SLE) with antiphospholipid syndrome. Clinical presentation of progressive lupus nephritis with intensifying renal insufficiency, arterial hypertension, hematuria, nephrotic syndrome was associated with unusual morphological manifestations of mesangiocapillary glomerulonephritis with advanced vasculitis. The authors attribute a malignant nephritis course atypical for patients with antiphospholipid syndrome to development of renal vasculitis. The discussion covers lupus genesis of vascular involvement, a probable triggering role of antibodies to phospholipids in impairment of endothelial cells.
报告了一例患有系统性红斑狼疮（SLE）合并抗磷脂综合征的女性患者发生快速进展性肾炎的病例。进行性狼疮性肾炎的临床表现为肾功能不全加重、动脉高血压、血尿、肾病综合征，伴有系膜毛细血管性肾小球肾炎伴晚期血管炎的不寻常形态学表现。作者将抗磷脂综合征患者非典型的恶性肾炎病程归因于肾血管炎的发展。讨论内容包括血管受累的狼疮发病机制，抗磷脂抗体在内皮细胞损伤中可能的触发作用。
