Zhang Huiwu, Li Xiuli, Xu Haiping, Ran Fang, Zhao Guoxia
Department III of Pediatric, Cangzhou Central Hospital Cangzhou, China.
Department II of Nephrology, Cangzhou Central Hospital Cangzhou, China.
Am J Transl Res. 2021 Jun 15;13(6):7065-7070. eCollection 2021.
To investigate the significance of the hemalexin C1q, retinal-binding-protein (RBP), and urinary N-acety1-β-D-glucosaminidase (NAG) levels in the diagnosis and prognosis of children with purpura nephritis.
A total of 130 children with purpura nephritis admitted to our hospital from January 2017 to December 2019 were recruited as the study cohort, including 43 children with purpura nephritis as the observation group, 51 children with purpura nephritis as the control group, and 36 healthy children undergoing physical examinations at the same time period as the healthy group. The basic data of the three groups of children were compared, and the hemalexin C1q, RBP, and urinary NAG levels were observed. The children were divided into a good prognosis group and a poor prognosis group according to the observation group's follow-up data. The significance of the hemalexin C1q, RBP, and urinary NAG levels for the diagnosis and prognosis of children with purpura nephritis was investigated by comparing the hemalexin C1q, RBP, and urinary NAG levels in these two groups.
The hemalexin C1q, RBP, and urinary NAG levels in the observation group, the control group, and the healthy group were significantly reduced, and the differences were statistically significant (P < 0.05). The hemalexin C1q, RBP, and urinary NAG levels of the children in the good prognosis group were significantly lower than they were in the poor prognosis group (P < 0.05).
The hemalexin C1q, RBP, and urinary NAG levels in the diagnosis and prognosis of children with purpura nephritis have a definite value and can be used as effective predictors for the prognosis of children with purpura nephritis.
探讨血抑素C1q、视网膜结合蛋白（RBP）及尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）水平在紫癜性肾炎患儿诊断及预后中的意义。
选取2017年1月至2019年12月我院收治的130例紫癜性肾炎患儿作为研究队列，其中43例紫癜性肾炎患儿为观察组，51例紫癜性肾炎患儿为对照组，同期36例健康体检儿童为健康组。比较三组儿童的基本资料，观察血抑素C1q、RBP及尿NAG水平。根据观察组随访资料将患儿分为预后良好组和预后不良组。通过比较两组患儿血抑素C1q、RBP及尿NAG水平，探讨其在紫癜性肾炎患儿诊断及预后中的意义。
观察组、对照组及健康组血抑素C1q、RBP及尿NAG水平均显著降低，差异有统计学意义（P<0.05）。预后良好组患儿血抑素C1q、RBP及尿NAG水平显著低于预后不良组（P<0.05）。
血抑素C1q、RBP及尿NAG水平在紫癜性肾炎患儿诊断及预后中具有一定价值，可作为紫癜性肾炎患儿预后的有效预测指标。
