Department of Psychiatry, Wenzhou Seventh People's Hospital, China.
Department of Pathology, Hangzhou Normal University, China.
J Alzheimers Dis. 2019;69(4):1161-1169. doi: 10.3233/JAD-181234.
Our aim was to examine whether the influence of apolipoprotein E4 (APOE4) genotype on cognitive decline differs in male and female across the Alzheimer's disease (AD) continuum. Among individuals with normal cognition (NC; n = 415), mild cognitive impairment (MCI; n = 870), and AD (n = 334), we investigated the longitudinal associations of APOE4 genotype and sex with cognitive decline over 13 years. Our cognitive outcomes were Rey Auditory Verbal Learning Test (RAVLT) total learning score and delayed recall and Mini-Mental State Examination (MMSE) score. There were significant effects of the APOE4×sex interaction on change in verbal memory in the MCI group, but not the NC or AD group. Specifically, among individuals with MCI, female APOE4 carriers had a steeper decline in RAVLT total learning score, but not delayed recall or MMSE score compared to all other groups (APOE4 + /Male, APOE4-/Female, APOE4-/Male). In conclusion, female APOE4 carriers have faster rates of memory decline than their male counterparts among MCI individuals.
我们的目的是检验载脂蛋白 E4（APOE4）基因型对阿尔茨海默病（AD）连续体中男性和女性认知衰退的影响是否不同。在认知正常（NC；n=415）、轻度认知障碍（MCI；n=870）和 AD（n=334）个体中，我们研究了 APOE4 基因型和性别与 13 年内认知衰退的纵向关联。我们的认知结果是 Rey 听觉言语学习测试（RAVLT）总学习得分和延迟回忆以及简易精神状态检查（MMSE）得分。APOE4×性别交互作用对 MCI 组的言语记忆变化有显著影响，但在 NC 或 AD 组则没有。具体来说，在 MCI 个体中，与其他所有组相比（APOE4+/男性、APOE4-/女性、APOE4-/男性），女性 APOE4 携带者的 RAVLT 总学习得分下降更快，但延迟回忆或 MMSE 得分则没有。总之，在 MCI 个体中，女性 APOE4 携带者的记忆衰退速度快于男性携带者。
