Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
Arch Oral Biol. 2019 Jul;103:26-32. doi: 10.1016/j.archoralbio.2019.05.014. Epub 2019 May 17.
Type 2 diabetes mellitus (T2DM) is a complex disease influenced by genes and the environment. Periodontitis a demonstrated risk factor of T2DM. Previous studies related to gene-environment interactions on the risk of T2DM mainly focused on gene-obesity interactions. However, the impact of gene-periodontitis interaction on the risk of T2DM has not yet been investigated. This study aimed to investigate gene-environment interactions among moderate/severe periodontitis, polymorphisms of adiponectin (ADIPOQ)-rs1501299, and leptin receptor (LEPR)-rs1137100 on T2DM risk in Chinese subjects.
A case-control study was conducted in 239 Chinese participants from Beijing Hypertension Association Institute (BHAL). After full-mouth periodontal examinations, the participants underwent bilateral buccal swabs for DNA testing. ADIPOQ-rs1501299 and LEPR-rs1137100 were used for genotyping. Generalised multifactor dimensionality reduction (GMDR) and logistic regression were used to examine the interactions among single nucleotide polymorphisms (SNPs) and moderate/severe periodontitis on the risk of T2DM.
The risk of T2DM was higher in moderate/severe periodontitis [adjusted odds ratio (AOR) = 3.67, 95% confidence interval (95%CI): 1.26-10.71] in ADIPOQ-rs1501299 GG genotype (AOR = 3.42, 95%CI: 1.81-6.46) and LEPR-rs1137100 GG genotype (AOR = 3.16, 95%CI: 1.56-6.39). The GMDR model indicated that there was a significant three-factor model (p = 0.001) involving rs1501299, rs1137100, and moderate/severe periodontitis, demonstrating a potential gene-environment interaction among periodontitis, polymorphisms of rs1501299, and rs1137100 influencing the risk of T2DM. Moderate/severe periodontitis patients with rs1501299-GG and rs1137100-GG have the highest T2DM risk after adjusting for age, gender, BMI, WHR, smoking status, alcohol consumption, economic status, and hypertension (AOR = 20.39, 95%CI: 2.64-157.26).
Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM. This study may provide a new insight into the effect of gene-environment interactions on T2DM.
2 型糖尿病（T2DM）是一种受基因和环境影响的复杂疾病。牙周炎是 T2DM 的一个明确危险因素。先前与基因-肥胖相互作用相关的 T2DM 风险的研究主要集中在基因-肥胖相互作用上。然而，基因-牙周炎相互作用对 T2DM 风险的影响尚未得到研究。本研究旨在调查中国人群中中重度牙周炎、脂联素（ADIPOQ）-rs1501299 多态性和瘦素受体（LEPR）-rs1137100 与 T2DM 风险之间的基因-环境相互作用。
本病例对照研究在北京高血压协会研究所（BHAL）的 239 名中国参与者中进行。在进行全口牙周检查后，参与者接受双侧颊部拭子进行 DNA 检测。ADIPOQ-rs1501299 和 LEPR-rs1137100 用于基因分型。广义多因素维度缩减（GMDR）和逻辑回归用于检查单核苷酸多态性（SNP）与中重度牙周炎之间与 T2DM 风险的相互作用。
中重度牙周炎患者 T2DM 风险较高[校正优势比（AOR）=3.67，95%置信区间（95%CI）：1.26-10.71]，ADIPOQ-rs1501299 GG 基因型（AOR=3.42，95%CI：1.81-6.46）和 LEPR-rs1137100 GG 基因型（AOR=3.16，95%CI：1.56-6.39）。GMDR 模型表明存在显著的三因素模型（p=0.001），涉及 rs1501299、rs1137100 和中重度牙周炎，表明牙周炎、rs1501299 和 rs1137100 多态性之间的基因-环境相互作用可能影响 T2DM 的风险。在调整年龄、性别、BMI、WHR、吸烟状况、饮酒状况、经济状况和高血压后，中重度牙周炎患者 rs1501299-GG 和 rs1137100-GG 具有最高的 T2DM 风险（AOR=20.39，95%CI：2.64-157.26）。
中重度牙周炎、rs1501299-GG 和 rs1137100-GG 之间的相互作用与 T2DM 风险增加相关。本研究可能为基因-环境相互作用对 T2DM 的影响提供新的见解。
Zotero 插件