Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School - FMRP/USP, Brazil.
Postgraduate Program in Pathology, Ribeirão Preto Medical School - FMRP/USP, Brazil.
J Tissue Viability. 2019 Aug;28(3):161-166. doi: 10.1016/j.jtv.2019.05.001. Epub 2019 May 20.
The aim of this study was to evaluate the impact of High Voltage Pulsed Current (HVPC) on the integration of total skin grafts in rats submitted to nicotine action.
For this purpose, 60 adult Wistar rats randomly distributed in 6 groups of 10 animals were analyzed. The electrical stimulation (anodic and cathodic stimulation, motor level, 30 min at 10 Hz; minimum voltage 20 μs and 100 μs pulse interval) was applied for seven days, starting on the third day after surgery and after the dressing was removed from the graft.
Anodic HVPC promoted greater graft integration, demonstrating a lower percentage of tissue contraction, a lower number of inflammatory infiltrates and a greater amount of vascular endothelial growth factor (VEGF), as well as a higher number of newly formed blood vessels.
HVPC can positively influence the integration of skin grafts in nicotine-treated rats. anodic HVPC is shown to promote greater integration in relation to a lower percentage of tissue contraction, a lower number of inflammatory infiltrates and a greater amount of vascular endothelial growth factor and newformed blood vessels. Whereas, the cathodic polarity has presented smaller amount of tissue gap.
本研究旨在评估高压脉冲电流（HVPC）对尼古丁作用下大鼠全层皮肤移植物整合的影响。
为此，将 60 只成年 Wistar 大鼠随机分为 6 组，每组 10 只动物。电刺激（阳极和阴极刺激，运动水平，10Hz 持续 30 分钟；最小电压 20μs 和 100μs 脉冲间隔）在手术后第三天开始，在移植物去除敷料后进行了七天。
阳极 HVPC 促进了更大的移植物整合，表现为组织收缩百分比更低，炎症浸润细胞数量更少，血管内皮生长因子（VEGF）更多，新生血管数量更多。
HVPC 可对尼古丁处理大鼠的皮肤移植物整合产生积极影响。与组织收缩百分比较低、炎症浸润细胞数量较少、血管内皮生长因子和新生血管较多相关，阳极 HVPC 显示出更大的整合作用。而阴极极性则表现出较小的组织间隙量。
