将接触过敏原 DNCB 及其类似物的结构和反应性与致敏潜能相关联。
Correlating the structure and reactivity of a contact allergen, DNCB, and its analogs to sensitization potential.
机构信息
Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.
出版信息
Bioorg Med Chem. 2019 Jul 1;27(13):2985-2990. doi: 10.1016/j.bmc.2019.05.017. Epub 2019 May 11.
Abstract
We report a study that seeks to find a correlation between the overall sensitization potential quantified by the expression of IL-8 by stimulated monocytes and the chemical structure of a model contact allergen, 2,4-dinitrochlorobenzene (DNCB). We show that structure and reactivity of the chemical compounds play an important role in activation of the monocytes and subsequent inflammation in tissue. However, we observed a non-linear correlation between the rate of reaction and biological activity indicating a required balance of stability and reactivity.
摘要
我们报告了一项研究，旨在寻找通过刺激单核细胞表达白细胞介素-8（IL-8）定量评估的整体致敏潜力与模型接触过敏原 2,4-二硝基氯苯（DNCB）的化学结构之间的相关性。我们表明，化学化合物的结构和反应性在单核细胞的激活以及随后的组织炎症中起着重要作用。然而，我们观察到反应速率和生物活性之间呈非线性相关，表明需要稳定性和反应性之间的平衡。
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