International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, 200438, PR China.
International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, 200438, PR China.
Cancer Lett. 2019 Aug 28;458:86-91. doi: 10.1016/j.canlet.2019.05.019. Epub 2019 May 24.
Tumor-associated macrophage (TAM) plays a prominent role in inflammatory microenvironment which contributes to hepatocellular carcinoma (HCC) progress by presenting M1 and M2 polarization. HCC, which is highly associated with inflammation, always leads to poor prognosis for recurrence and metastasis. TAMs with M2 polarization induce cellular proliferation, angiogenesis, epithelial-mesenchymal transition (EMT) in HCC. Furthermore, it also interacts with other immune cell clusters which leads to the resistance in targeted therapy and immunotherapy. This article reviews studies on the role of TAM to affect HCC treatment and provides insight into the potential individualized precision monotherapy or combination therapy in HCC.
肿瘤相关巨噬细胞（TAM）在炎症微环境中发挥着重要作用，通过 M1 和 M2 极化促进肝细胞癌（HCC）的进展。HCC 与炎症密切相关，总是导致复发和转移的预后不良。具有 M2 极化的 TAMs 诱导 HCC 中的细胞增殖、血管生成、上皮-间充质转化（EMT）。此外，它还与其他免疫细胞群相互作用，导致靶向治疗和免疫治疗的耐药性。本文综述了 TAM 影响 HCC 治疗的作用研究，并为 HCC 的潜在个体化精准单药或联合治疗提供了新的见解。
