大鼠肝脏中蛋白A对谷胱甘肽-S-转移酶同工酶的诱导作用。
Induction of glutathione-S-transferase isoenzymes by protein A in rat liver.
作者信息
Dwivedi P P, Kumar A, Prasad A K, Pandya K P, Ray P K
机构信息
Industrial Toxicology Research Centre, Lucknow, India.
出版信息
Biochem Biophys Res Commun. 1990 Jun 15;169(2):476-81. doi: 10.1016/0006-291x(90)90356-r.
The administration of Protein A, a cell wall protein of Staphylococcus aureus Cowan I cells, causes an induction of glutathione-s-transferase in rat liver. Proteins, cross reactive with anti human glutathione-s-transferase, acidic (pi), basic (alpha, and neutral (mu) isoenzymes, are induced by 5.8, 2.2 and 6.15 fold respectively. The induction of glutathione -s-transferases, at least in part, might play a role in manifestation of therapeutic properties of Protein A.
给予金黄色葡萄球菌考恩I型细胞的细胞壁蛋白A可诱导大鼠肝脏中的谷胱甘肽 - S - 转移酶。与抗人谷胱甘肽 - S - 转移酶发生交叉反应的蛋白质，即酸性（pi）、碱性（α）和中性（μ）同工酶，分别被诱导了5.8倍、2.2倍和6.15倍。谷胱甘肽 - S - 转移酶的诱导至少在一定程度上可能在蛋白A治疗特性的表现中发挥作用。
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