长链非编码 RNA TP73-AS1 在非小细胞肺癌中上调，并预测不良预后。
LncRNA TP73-AS1 is upregulated in non-small cell lung cancer and predicts poor survival.
机构信息
Endoscopic Center of Zhejiang Cancer Hospital, No. 1 Banshan Road, Gongshu District, Hangzhou City, Zhejiang Province 310022, PR China.
Endoscopic Center of Zhejiang Cancer Hospital, No. 1 Banshan Road, Gongshu District, Hangzhou City, Zhejiang Province 310022, PR China.
出版信息
Gene. 2019 Aug 20;710:98-102. doi: 10.1016/j.gene.2019.05.044. Epub 2019 May 23.
The present study was carried out to investigate the role of lncRNA TP73-AS1 in non-small cell lung cancer (NSCLC). We found that TP73-AS1 was upregulated in tumor tissues than in non-tumor tissues of NSCLC patients, and high expression levels of TP73-AS1 predicted poor survival. MiR-21 was also upregulated in tumor tissues and positively correlated with TP73-AS1. TP73-AS1 overexpression led to miR-21 upregulation, while miR-21 overexpression failed to affect TP73-AS1. TP73-AS1 and miR-21 overexpression caused the accelerated invasion and migration of NSCLC cells. However, TP73-AS1 overexpression failed to affect cell proliferation. Therefore, TP73-AS1 may upregulate miR-21 to promote NSCLC cell migration and invasion.
本研究旨在探讨长链非编码 RNA TP73-AS1 在非小细胞肺癌（NSCLC）中的作用。我们发现，TP73-AS1 在 NSCLC 患者的肿瘤组织中上调，高于非肿瘤组织，高水平的 TP73-AS1 预示着不良的生存。miR-21 在肿瘤组织中也上调，并与 TP73-AS1 呈正相关。TP73-AS1 的过表达导致 miR-21 的上调，而 miR-21 的过表达未能影响 TP73-AS1。TP73-AS1 和 miR-21 的过表达导致 NSCLC 细胞侵袭和迁移的加速。然而，TP73-AS1 的过表达未能影响细胞增殖。因此，TP73-AS1 可能通过上调 miR-21 来促进 NSCLC 细胞的迁移和侵袭。
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