Wolff C H
Scand J Immunol. 1987 Jul;26(1):7-10. doi: 10.1111/j.1365-3083.1987.tb02228.x.
The kinetics of Ca2+ uptake into lectin-induced secondary lymphocytes was studied during reactivation to DNA synthesis with concanavalin A (Con A) or interleukin 2 (IL-2). IL-2 did not cause any significant uptake of Ca2+ into the lymphocytes, while Con A induced an accumulation of Ca2+ into the lymphocytes which reached a maximum 1 to 2 h after the addition of the lectin. The time during which Ca2+ uptake occurred corresponded to the time of dependence on extracellular Ca2+ for lectin-induced DNA synthesis. The increased rate of Ca2+ accumulation and the shortened Ca2+ dependence period of secondary lymphocytes as compared with primary lymphocytes could explain the ability of secondary lymphocytes to display an accelerated response, in terms of DNA synthesis, to re-stimulus.
在使用伴刀豆球蛋白A（Con A）或白细胞介素2（IL - 2）使淋巴细胞重新激活进入DNA合成阶段的过程中，研究了凝集素诱导的次级淋巴细胞摄取Ca2+的动力学。IL - 2未引起淋巴细胞对Ca2+的任何显著摄取，而Con A诱导淋巴细胞摄取Ca2+，在添加凝集素后1至2小时达到最大值。Ca2+摄取发生的时间与凝集素诱导的DNA合成对细胞外Ca2+的依赖时间相对应。与原代淋巴细胞相比，次级淋巴细胞Ca2+积累速率增加且Ca2+依赖期缩短，这可以解释次级淋巴细胞在DNA合成方面对再次刺激显示出加速反应的能力。
