Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Curr Opin Pharmacol. 2019 Dec;49:34-42. doi: 10.1016/j.coph.2019.04.018. Epub 2019 May 24.
The microbiome mediates constant bidirectional communication with the host immune system in a delicate balance of inducing pathogenic infection or residing in the human body in a commensal state. Dysbiosis is a hallmark of several autoimmune and immune-mediated inflammatory diseases. Various pathways involved in microbiome-induced autoimmunity are activated when a genetic defect or microbial trigger is found in the inflammasome, neutrophil extracellular trap, or receptors for microbial sensitization in the innate immune system or when similar defects are present in T or B lymphocytes of the adaptive immune system. Regulating autoimmunity through microbiome modulation may be highly effective as a therapeutic intervention.
微生物组与宿主免疫系统保持着微妙的平衡，不断进行双向通讯，既能诱导病原感染，也能与人体共生。微生态失调是多种自身免疫性和免疫介导的炎症性疾病的特征。当先天免疫系统中的炎性小体、中性粒细胞胞外诱捕网或微生物致敏受体中存在遗传缺陷或微生物触发因素，或适应性免疫系统中的 T 或 B 淋巴细胞存在类似缺陷时，微生物组诱导自身免疫的各种途径被激活。通过微生物组调节来调节自身免疫可能是一种非常有效的治疗干预措施。
