de Jong Lutea A A, Olyslager Erik J H, Duijst Wilma L J M
Department of Clinical Pharmacy, Gelre Hospitals, P.O. Box 9014, 7300 DS, Apeldoorn, the Netherlands.
Department of Clinical Pharmacy, Gelre Hospitals, P.O. Box 9014, 7300 DS, Apeldoorn, the Netherlands.
J Forensic Leg Med. 2019 Jul;65:101-104. doi: 10.1016/j.jflm.2019.05.011. Epub 2019 May 21.
Structural analogs of classic drugs, also called designer drugs, are a booming market due to the easy accessibility on the internet and their legal status. One of those 'legal highs' is an analog of phencyclidine, namely 3-methoxyphencyclidine (3-MeO-PCP). Very few fatalities have been reported where 3-MeO-PCP contributed to the death of an individual. We present the first fatal case in the Netherlands and one of the few worldwide. Postmortem biological samples and the presumed abused unknown substance, sold as ant poison, were obtained. 3-MeO-PCP was detected, and the resulting concentration was 152 μg/l in whole blood. The presumed taken unknown sample was identified as 3-MeO-PCP and thus linked to the victim. The cause of death was a combination of 3-MeO-PCP, amphetamine, and alcohol. Improved diagnostic skills are necessary to face these emerging novel psychoactive substances also in light of public health and social risks.
经典药物的结构类似物，也被称为设计药物，由于在互联网上易于获取及其法律地位，正成为一个蓬勃发展的市场。其中一种“合法兴奋剂”是苯环己哌啶的类似物，即3-甲氧基苯环己哌啶（3-MeO-PCP）。很少有报道称3-MeO-PCP导致个体死亡。我们报告了荷兰的首例死亡病例，也是全球为数不多的此类病例之一。获取了尸检生物样本以及被当作灭鼠药出售的疑似滥用的未知物质。检测到了3-MeO-PCP，全血中的浓度为152μg/l。疑似服用的未知样本被鉴定为3-MeO-PCP，从而与受害者建立了关联。死亡原因是3-MeO-PCP、苯丙胺和酒精共同作用的结果。鉴于公共卫生和社会风险，提高诊断技能对于应对这些新出现的新型精神活性物质也是必要的。
