Department of General and Experimental Pathology, Medical University of Białystok, Mickiewicza 2c, 15-222, Białystok, Poland.
Behav Genet. 2019 Jul;49(4):415-423. doi: 10.1007/s10519-019-09959-6. Epub 2019 May 25.
Chronic peripheral elevation of interleukin 6 (IL-6) in humans is associated with cognitive deficits. 4- and 24-month-old IL-6-deficient C57BL/6J (IL-6KO) and reference wild-type (WT) mice were tested in an object recognition test. Discrimination ratios and recognition indexes were significantly lower in 4-month-old IL-6KO and in 24-month-old WT mice vs 4-month-old WT animals. Their discrimination ratios had negative values and recognition indexes were below 50% indicating inability to differentiate the novel from the familiar object after 1-hour delay. In 24-month-old IL-6KO mice recognition index reached 53.17% indicating that their recognition memory was not worsened with age in comparison with younger IL-6-deficient animals. Results of holeboard and elevated plus maze indicated that this effect was memory specific. Inborn IL-6 deficiency attenuated recognition memory in 4-month-old mice and did not altered recognition memory in aged animals. IL-6 signalling may constitute a target for development of the protection against memory disturbances connected with IL-6 overexpression.
慢性外周性白细胞介素 6（IL-6）升高与人类认知缺陷有关。4 月龄和 24 月龄的 IL-6 缺陷 C57BL/6J（IL-6KO）和参考野生型（WT）小鼠在物体识别测试中进行了测试。4 月龄的 IL-6KO 和 24 月龄的 WT 小鼠的辨别率和识别指数明显低于 4 月龄的 WT 动物。它们的辨别率呈负值，识别指数低于 50%，表明在 1 小时延迟后，它们无法区分新物体和熟悉物体。24 月龄的 IL-6KO 小鼠的识别指数达到 53.17%，表明与年轻的 IL-6 缺陷动物相比，其认知记忆并未随年龄增长而恶化。洞板和高架十字迷宫的结果表明，这种效应是记忆特异性的。先天性 IL-6 缺乏会减弱 4 月龄小鼠的识别记忆，但不会改变老年动物的识别记忆。IL-6 信号可能是开发针对与 IL-6 过表达相关的记忆障碍的保护措施的靶标。
