Alemayehu Tinsae, Hailu Daniel
Department of Pediatrics and child health, College of health sciences, Addis Ababa University, Addis Ababa, Ethiopia.
J Med Case Rep. 2019 May 27;13(1):158. doi: 10.1186/s13256-019-2099-3.
Hepatocellular carcinoma in children with hepatitis B virus infection is rarely reported. Metastases to the vertebrae are an even more unusual phenomenon.
We report on a case of a 10-year-old Ethiopian boy with hepatitis B infection presenting with paraplegia and incontinence of 10 days' duration. A diagnosis of hepatocellular carcinoma with vertebral metastases was confirmed with serum α-fetoprotein, fine-needle aspirate cytology, and abdominal imaging.
Surveillance of children not immunized against hepatitis B virus prevents infection and its complications, such as hepatocellular carcinoma. Among children in endemic countries prone to development of hepatocellular carcinoma, metastatic disease can present as sudden weakness of extremities with radiologic findings of vertebral body collapse.
乙肝病毒感染儿童发生肝细胞癌的报道很少。转移至椎骨更是一种罕见现象。
我们报告一例10岁埃塞俄比亚男孩，患有乙肝感染，出现截瘫和持续10天的大小便失禁。通过血清甲胎蛋白、细针穿刺细胞学检查和腹部影像学检查确诊为肝细胞癌伴椎骨转移。
对未接种乙肝疫苗的儿童进行监测可预防感染及其并发症，如肝细胞癌。在易发生肝细胞癌的流行国家的儿童中，转移性疾病可表现为肢体突然无力，并伴有椎体塌陷的影像学表现。
