Rousan Talla A, Thadani Udho
University of Oklahoma Health Sciences Center and Veteran Affairs Medical Center, Oklahoma City Oklahoma, US.
Eur Cardiol. 2019 Apr;14(1):18-22. doi: 10.15420/ecr.2018.26.1.
Most patients with stable angina can be managed with lifestyle changes, especially smoking cessation and regular exercise, along with taking antianginal drugs. Randomised controlled trials show that antianginal drugs are equally effective and none of them reduced mortality or the risk of MI, yet guidelines prefer the use of beta-blockers and calcium channel blockers as a first-line treatment. The European Society of Cardiology guidelines for the management of stable coronary artery disease provide classes of recommendation with levels of evidence that are well defined. The National Institute for Health and Care Excellence (NICE) guidelines for the management of stable angina provide guidelines based on cost and effectiveness using the terms first-line and second-line therapy. Both guidelines recommend using low-dose aspirin and statins as disease-modifying agents. The aim of this article is to critically appraise the guidelines' pharmacological recommendations for managing patients with stable angina.
大多数稳定型心绞痛患者可通过改变生活方式来控制病情,尤其是戒烟和规律运动,同时服用抗心绞痛药物。随机对照试验表明,抗心绞痛药物疗效相当,且无一能降低死亡率或心肌梗死风险,但指南更倾向于将β受体阻滞剂和钙通道阻滞剂作为一线治疗药物。欧洲心脏病学会稳定型冠状动脉疾病管理指南提供了定义明确的推荐类别和证据水平。英国国家卫生与临床优化研究所(NICE)稳定型心绞痛管理指南根据成本效益给出了一线和二线治疗的指南。两个指南均推荐使用小剂量阿司匹林和他汀类药物作为病情改善药物。本文旨在严格评估这些指南中关于稳定型心绞痛患者管理的药理学推荐。