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YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma.

作者信息

Bai Yang, Yang Chunxing, Wu Runliu, Huang Lihua, Song Shenlei, Li Wanwan, Yan Peichen, Lin Changwei, Li Daojiang, Zhang Yi

机构信息

Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.

Center for Medical Experiments, The Third Xiangya Hospital of Central South University, Changsha, China.

出版信息

Front Oncol. 2019 May 3;9:332. doi: 10.3389/fonc.2019.00332. eCollection 2019.

DOI:10.3389/fonc.2019.00332
PMID:31131257
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6509179/
Abstract

YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1) is a core factor in RNA methylation modification. Recent studies have shown that m6A is closely related to multiple tumors, thus YTHDF1 may also play a role in tumorigenesis. This study, aimed to explore the role of YTHDF1 in the colorectal cancer (CRC). In this study, we identified YTHDF1 as being highly expressed at the mRNA and protein levels in TCGA, GEO CRC and primary CRC. Furthermore, the YTHDF1 gene copy number was positively correlated with YTHDF1 mRNA expression in CRC. Knocking down the expression of YTHDF1 significantly inhibited the CRC cell's tumorigenicity and murine xenograft tumor growth . Furthermore, silencing of YTHDF1 inhibited the colonosphere formation ability . Mechanistically, we found that silencing YTHDF1 significantly inhibited Wnt/β-catenin pathway activity in CRC cells. Together, YTHDF1 is overexpressed in CRC and plays a vital oncogenic role in CRC, and this novel finding may provide a potential therapeutic target for CRC.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/0a7dff0e74dd/fonc-09-00332-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/4f79778abee8/fonc-09-00332-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/31fa2469a3ee/fonc-09-00332-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/a4b994a4ac8c/fonc-09-00332-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/70faa60b8793/fonc-09-00332-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/bc0da1d14df4/fonc-09-00332-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/e69ac49f5f88/fonc-09-00332-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/0a7dff0e74dd/fonc-09-00332-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/4f79778abee8/fonc-09-00332-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/31fa2469a3ee/fonc-09-00332-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/a4b994a4ac8c/fonc-09-00332-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/70faa60b8793/fonc-09-00332-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/bc0da1d14df4/fonc-09-00332-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/e69ac49f5f88/fonc-09-00332-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a8b/6509179/0a7dff0e74dd/fonc-09-00332-g0007.jpg

相似文献

[1]
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma.

Front Oncol. 2019-5-3

[2]
N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer.

Gastroenterology. 2022-4

[3]
YTHDF1 Enhances Chondrogenic Differentiation by Activating the Wnt/β-Catenin Signaling Pathway.

Stem Cells Dev. 2023-3

[4]
Identification and Validation of the N6-Methyladenosine RNA Methylation Regulator YTHDF1 as a Novel Prognostic Marker and Potential Target for Hepatocellular Carcinoma.

Front Mol Biosci. 2020-12-10

[5]
YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness.

EMBO Rep. 2020-4-3

[6]
Up-Regulation of SH3TC2 Induced by YTHDF1 Predicts Poor Outcome and Facilitates Cell-Cycle Progress in Colorectal Cancer.

J Oncol. 2022-12-15

[7]
YTHDF1-enhanced iron metabolism depends on TFRC mA methylation.

Theranostics. 2020

[8]
ELK1-mediated YTHDF1 drives prostate cancer progression by facilitating the translation of Polo-like kinase 1 in an m6A dependent manner.

Int J Biol Sci. 2022

[9]
RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis.

Cancer Res. 2024-9-4

[10]
YTHDF1 Aggravates the Progression of Cervical Cancer Through mA-Mediated Up-Regulation of RANBP2.

Front Oncol. 2021-3-19

引用本文的文献

[1]
RNA mA modification: a key regulator in normal and malignant processes.

Cell Investig. 2025-6

[2]
Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance.

Signal Transduct Target Ther. 2025-7-18

[3]
METTL14-mediated miR-122-5p maturation stimulated tumor progression by targeting KAT2A in hepatocellular carcinoma.

Sci Rep. 2025-5-23

[4]
Effects of Benzo[a]Pyrene Exposure on Lung Cancer: A Mechanistic Study of Epigenetic m6A Levels and YTHDF1.

Toxics. 2025-4-5

[5]
YTHDF1/RNF7/p27 axis promotes prostate cancer progression.

Cell Death Dis. 2025-4-18

[6]
Interplay of m6A RNA methylation and gut microbiota in modulating gut injury.

Gut Microbes. 2025-12

[7]
N-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.

Clin Transl Med. 2025-2

[8]
m1A-regulated DIAPH3 promotes the invasiveness of colorectal cancer via stabilization of KRT19.

Clin Exp Metastasis. 2025-1-22

[9]
Prognostic significance and identification of m6A regulator genes and hub genes associated with m6A in breast cancer.

Discov Oncol. 2024-11-12

[10]
N6-Methyladenosine methylation modification in breast cancer: current insights.

J Transl Med. 2024-10-28

本文引用的文献

[1]
Anti-tumour immunity controlled through mRNA mA methylation and YTHDF1 in dendritic cells.

Nature. 2019-2-6

[2]
RIF1 promotes tumor growth and cancer stem cell-like traits in NSCLC by protein phosphatase 1-mediated activation of Wnt/β-catenin signaling.

Cell Death Dis. 2018-9-20

[3]
Stem cell fate in cancer growth, progression and therapy resistance.

Nat Rev Cancer. 2018-11

[4]
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

CA Cancer J Clin. 2018-9-12

[5]
mA mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.

Nat Cell Biol. 2018-8-27

[6]
Suppression of mA reader Ythdf2 promotes hematopoietic stem cell expansion.

Cell Res. 2018-7-31

[7]
Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma.

Theranostics. 2018-6-7

[8]
DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.

Oncogene. 2018-3-14

[9]
Oncogene c-Myc promotes epitranscriptome mA reader YTHDF1 expression in colorectal cancer.

Oncotarget. 2017-12-21

[10]
Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma.

Cancer Biomark. 2018

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