Dhiman Gourav, Srivastava Neha, Goyal Mehendi, Rakha Emad, Lothion-Roy Jennifer, Mongan Nigel P, Miftakhova Regina R, Khaiboullina Svetlana F, Rizvanov Albert A, Baranwal Manoj
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, India.
Faculty of Medicine and Health Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
Front Oncol. 2019 May 3;9:349. doi: 10.3389/fonc.2019.00349. eCollection 2019.
Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in various aspects of cancer progression and metastasis. Elevated expression of MTDH/AEG-1 has been reported in many cancers including breast, prostate, liver, and esophageal cancers, whereas its expression is low or absent in non-malignant tissues. These expression studies suggest that MTDH may represent a potential tumor associated antigen. MTDH also regulates multiple signaling pathways including PI3K/Akt, NF-κB, Wnt/β-catenin, and MAPK which cooperate to promote the tumorigenic and metastatic potential of transformed cells. Several microRNA have also been found to be associated with the increased MTDH expression in different cancers. Increased MTDH levels were linked to the tumor chemoresistance making it an attractive novel therapeutic target. In this review, we summarize data on MTDH function in various cancers.
许多基因和蛋白质的表达改变对于癌症的发生和发展至关重要。最近，黏附素（MTDH）的表达受到影响，MTDH也被称为星形胶质细胞上调基因1（AEG-1）和Lyric，它与癌症进展和转移的各个方面都有关联。在包括乳腺癌、前列腺癌、肝癌和食管癌在内的许多癌症中，都报道了MTDH/AEG-1的表达升高，而在非恶性组织中其表达较低或不存在。这些表达研究表明，MTDH可能代表一种潜在的肿瘤相关抗原。MTDH还调节多种信号通路，包括PI3K/Akt、NF-κB、Wnt/β-连环蛋白和MAPK，这些信号通路共同促进转化细胞的致瘤和转移潜能。还发现几种微小RNA与不同癌症中MTDH表达的增加有关。MTDH水平的升高与肿瘤化疗耐药性有关，这使其成为一个有吸引力的新型治疗靶点。在这篇综述中，我们总结了关于MTDH在各种癌症中功能的数据。
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