线粒体编码的MOTS-c对细胞核转录的调控
Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c.
作者信息
Lee Changhan
机构信息
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
出版信息
Mol Cell Oncol. 2019 Feb 15;6(2):1549464. doi: 10.1080/23723556.2018.1549464. eCollection 2019.
Cellular stress response is coordinated through the communication between mitochondria and the nucleus. However, whereas mitochondria are regulated by nuclear-encoded proteins, the nucleus was considered ungoverned by mitochondrial-encoded factors. We recently reported that a mitochondrial-encoded peptide directly regulates the nuclear genome upon cellular stress, indicating an integrated bi-genomic cross-communication mechanism.
细胞应激反应是通过线粒体与细胞核之间的通讯来协调的。然而，尽管线粒体由核编码蛋白调控，但细胞核曾被认为不受线粒体编码因子的控制。我们最近报道，一种线粒体编码的肽在细胞应激时直接调控核基因组，这表明存在一种双基因组整合的交叉通讯机制。
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