Morishita Shinichiro, Tsubaki Atsuhiro, Hotta Kazuki, Fu Jack B, Fuji Shigeo
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan, Tel: +81-25-257-4300.
Department of Palliative, Rehabilitation & Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA, Tel: +1-713-745- 2327.
J Int Soc Phys Rehabil Med. 2019 Jan-Mar;2(1):54-61. doi: 10.4103/jisprm.jisprm_2_19. Epub 2019 May 22.
Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is increasingly used in the treatment of hematologic cancers such as leukemias, lymphomas, and myeloma, and for other hematologic disorders such as primary immunodeficiency, aplastic anemia, and myelodysplasia. Allo-HSCT entails a conditioning regimen of frequent high-dose chemotherapy in combination with total body irradiation, followed by infusion of donor-harvested bone marrow or peripheral blood stem cells. As an aggressive and demanding medical therapy that profoundly impacts patient quality of life (QOL), allo-HSCT is associated with numerous treatment-related physical, psychological, and psychosocial side effects. The procedure can result in decreased respiratory and balance function, skeletal muscle strength, and exercise capacity. Thus, as physical exercise has been shown to positively effect physical and psychosocial function and QOL in allo-HSCT patients, it is a recommended intervention for improving essential functions and offsetting lost exercise capacity after the procedure. Furthermore, recent evidence has shown that physical exercise can influence survival rate and mortality in allo-HSCT patients. This review provides an overview of the current research on the effectiveness of physical exercise for allo-HSCT patients.
异基因造血干细胞移植（allo-HSCT）越来越多地用于治疗白血病、淋巴瘤和骨髓瘤等血液系统癌症，以及原发性免疫缺陷、再生障碍性贫血和骨髓增生异常综合征等其他血液系统疾病。Allo-HSCT需要进行频繁的高剂量化疗联合全身照射的预处理方案，随后输注供体采集的骨髓或外周血干细胞。作为一种对患者生活质量（QOL）有深远影响的激进且要求苛刻的医学治疗方法，allo-HSCT会带来许多与治疗相关的身体、心理和社会心理副作用。该手术可能导致呼吸和平衡功能、骨骼肌力量以及运动能力下降。因此，由于体育锻炼已被证明对allo-HSCT患者的身体和社会心理功能以及生活质量有积极影响，它是改善术后基本功能和弥补运动能力丧失的推荐干预措施。此外，最近的证据表明体育锻炼可以影响allo-HSCT患者的生存率和死亡率。本综述概述了当前关于体育锻炼对allo-HSCT患者有效性的研究。
