Department of Rehabilitation, Hyogo College of Medicine Hospital, Nishinomiya, Hyogo, Japan.
Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Adv Exp Med Biol. 2018;1072:287-291. doi: 10.1007/978-3-319-91287-5_46.
Impaired oxygen utilization in skeletal muscle potentially contributes to muscle weakness in patients with malignant hematopoietic disease and may explain altered hemodynamic responses to exercise in these patients. We investigated whether changes in hemoglobin parameters in the tibialis anterior muscle in patients with malignant hematopoietic diseases were different from those in age-matched healthy controls and whether these results were associated with a decline in muscle strength. Near-infrared spectroscopy was used during and after a repeated isometric contraction task at 50% of maximal voluntary contraction in 16 patients and 21 age- and sex-matched healthy controls. In the healthy control group, there was a correlation between muscle strength and hemoglobin dynamics, (ΔtHbmean: r = 0.42, p < 0.05; ΔtHbmax: r = 0.575, p < 0.01, respectively) but not in patients with malignant hematopoietic disease. The results of this study may suggest that haemoglobin dynamics during and following exercise were different between patients with malignant hematopoietic disease and healthy controls.
骨骼肌氧利用受损可能导致恶性血液疾病患者的肌肉无力，并可能解释这些患者运动时血液动力学反应的改变。我们研究了恶性血液疾病患者胫骨前肌的血红蛋白参数变化是否与年龄匹配的健康对照组不同，以及这些结果是否与肌肉力量下降有关。在 16 名患者和 21 名年龄和性别匹配的健康对照组中，使用近红外光谱技术在 50%最大自主收缩的重复等长收缩任务期间和之后进行测量。在健康对照组中，肌肉力量与血红蛋白动力学之间存在相关性（ΔtHbmean：r = 0.42，p < 0.05；ΔtHbmax：r = 0.575，p < 0.01），但在恶性血液疾病患者中则没有。本研究结果可能表明，恶性血液疾病患者和健康对照组在运动期间和之后的血红蛋白动力学不同。
