Meyer Alexander, Dandamudi Sanjay, Achenbach Chad, Lloyd-Jones Donald, Feinstein Matthew
1 Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
2 Spectrum Health Heart and Vascular Institute, Grand Rapids, MI, USA.
J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958219852123. doi: 10.1177/2325958219852123.
Persons with HIV have elevated risk for cardiovascular disease, but little is known about the risk of ventricular ectopy and ventricular tachycardia (VE/VT) for HIV-infected (HIV+) persons.
We evaluated the presence and anatomic origin of VE/VT for HIV+ persons and controls by screening a cohort using International Classification of Diseases codes and adjudicating positive screens by chart review. We sought to evaluate (1) presence of VE/VT and (2) likely anatomic origin of the VE/VT based on electrocardiogram.
There was no significant difference in the prevalence of VE/VT for HIV+ or uninfected persons. Among HIV+ persons, worse HIV control was associated with significantly greater odds of VE/VT. Exploratory analyses suggested that HIV+ persons may have a greater likelihood of VE/VT originating from the left ventricle.
Although worse HIV control was associated with higher odds of VE/VT among persons with HIV, odds of VE/VT were not higher for persons with HIV than uninfected persons.
感染HIV的人患心血管疾病的风险升高，但对于HIV感染者（HIV+）发生室性早搏和室性心动过速（VE/VT）的风险了解甚少。
我们通过使用国际疾病分类代码筛查队列并通过病历审查判定阳性筛查结果，评估了HIV+人群和对照组中VE/VT的存在情况及其解剖学起源。我们试图评估（1）VE/VT的存在情况以及（2）基于心电图的VE/VT可能的解剖学起源。
HIV+人群或未感染人群中VE/VT的患病率无显著差异。在HIV+人群中，HIV控制较差与VE/VT的显著更高几率相关。探索性分析表明，HIV+人群发生源自左心室的VE/VT的可能性可能更大。
虽然在HIV感染者中，HIV控制较差与VE/VT的更高几率相关，但HIV感染者发生VE/VT的几率并不高于未感染人群。
