Iwamasa T, Ohshita T, Nashiro K, Iwanaga M
Acta Neuropathol. 1987;73(4):357-60. doi: 10.1007/BF00688259.
By using cholera toxin B subunit and its antibody, the deposition of GM1-ganglioside in the cerebral cortex and peripheral nerves including Meissner and Auerbach's plexuses in the intestine and other visceral nerves of generalized GM1-gangliosidosis was demonstrated. The GM1-ganglioside was found in the swollen neurons of cerebral cortex and ganglion cells of the peripheral nerves. Electron microscopically, parts of membranous cytoplasmic bodies, and amorphous substances among them, revealed a positive reaction for the cholera toxin staining.
通过使用霍乱毒素B亚基及其抗体，在全身性GM1神经节苷脂沉积症中，证实了GM1神经节苷脂在大脑皮质以及包括肠道中的迈斯纳丛和奥尔巴赫丛在内的周围神经及其他内脏神经中的沉积。在大脑皮质肿胀的神经元和周围神经节细胞中发现了GM1神经节苷脂。电子显微镜检查显示，部分膜性细胞质小体及其间的无定形物质对霍乱毒素染色呈阳性反应。
