Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Biomedical Engineering Research Group, Department of Mechanical and Mechatronic Engineering, Stellenbosch University, Stellenbosch, South Africa.
Int J Gynaecol Obstet. 2019 Aug;146(2):250-256. doi: 10.1002/ijgo.12873.
To evaluate the association between birthweight and maternal heart rate (MHR) or heart rate variability (HRV) under resting conditions at 20-24 gestational weeks and 34 weeks or later (34+ weeks).
Data were retrospectively reviewed from the Safe Passage Study, a prospective longitudinal cohort study of alcohol use in pregnancy and birth outcomes in Cape Town, South Africa, between August 2007 and January 2015. Using custom-designed software, MHR and indicators of HRV were obtained from the recorded maternal electrocardiograms and compared with birthweight and z-scores of birthweight adjusted for gestation and gender.
Data from 5655 women were included. MHR increased from 84.6 bpm at 20-24 weeks to 88.3 bpm at 34+ weeks. Increasing MHR from 70-80 to 80-90 and 90-100 bpm at 20-24 weeks was associated with increasing birthweight from 2940 to 2998 and 3032 g, respectively (P<0.05). MHR and HRV contributed 29% to the variability associated with birthweight, whereas maternal body mass index at recruitment contributed 44%. Similar associations were observed for MHR at 34+ weeks.
The observed association of low maternal heart rate with birthweight might help to identify pregnancies at risk of poor fetal growth.
评估 20-24 孕周和 34 孕周及以后（34+ 周）孕妇静息状态下的心率（MHR）或心率变异性（HRV）与出生体重之间的关系。
本研究数据来自南非开普敦 Safe Passage 研究，该研究是一项关于孕期饮酒与出生结局的前瞻性纵向队列研究，于 2007 年 8 月至 2015 年 1 月期间进行。使用定制软件从记录的母体心电图中获取 MHR 和 HRV 指标，并与出生体重和性别调整后的出生体重 z 分数进行比较。
共纳入 5655 名女性的数据。MHR 从 20-24 孕周的 84.6bpm 增加到 34+ 孕周的 88.3bpm。20-24 孕周时，MHR 从 70-80bpm 增加到 80-90bpm 和 90-100bpm 时，出生体重分别增加到 2940g、2998g 和 3032g（P<0.05）。MHR 和 HRV 对出生体重的变异性有 29%的贡献，而招募时的母体体重指数则有 44%的贡献。34+ 孕周时的 MHR 也观察到了类似的相关性。
观察到的孕妇低心率与出生体重之间的关联可能有助于识别胎儿生长不良的高危妊娠。
