Kobayashi Kazuyoshi, Imagama Shiro, Ando Kei, Machino Masaaki, Ota Kyotaro, Tanaka Satoshi, Morozumi Masayoshi, Kanbara Shunsuke, Ito Sadayuki, Ishiguro Naoki, Hasegawa Yukiharu
Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Rehabilitation, Kansai University of Welfare Science, Osaka, Japan.
Mod Rheumatol. 2020 May;30(3):592-597. doi: 10.1080/14397595.2019.1623455. Epub 2019 Jun 17.
To determine the prevalence of osteosarcopenia and its relationship with physical function in elderly people in Japan. The subjects were 427 healthy volunteers over 65 years old (205 males, 222 females, average age 71.4 years) who attended health checkups in 2016 and 2017. Body mass index (BMI), bone mineral density in the calcaneus (%YAM), physical parameters, and skeletal muscle mass were measured. The appendicular skeletal muscle index (aSMI) was calculated as arm and leg skeletal muscle mass/height. Osteoporosis was defined as %YAM < 70%, sarcopenia as aSMI < 7.0 kg/m (males) and <5.8 kg/m (females), and osteosarcopenia as the presence of sarcopenia and osteoporosis. Osteoporosis alone was diagnosed in 60 subjects (14%), sarcopenia alone in 55 (13%), and osteosarcopenia in 36 (8%). The prevalence of osteosarcopenia was 8% in all subjects, 12% in females, and 4% in males. BMI and back muscle strength were significantly lower in osteosarcopenia than in sarcopenia alone ( < .05); and weight, BMI, body fat, grip strength, and back muscle strength were significantly lower in osteosarcopenia than in osteoporosis alone ( < .05). Osteosarcopenia was significantly associated with muscle weakness. Further studies to identify other related factors are needed for prevention and treatment of osteosarcopenia.
为了确定日本老年人中骨质疏松性肌少症的患病率及其与身体功能的关系。研究对象为2016年和2017年参加健康体检的427名65岁以上的健康志愿者（男性205名，女性222名，平均年龄71.4岁）。测量了体重指数（BMI）、跟骨骨密度（%YAM）、身体参数和骨骼肌质量。计算四肢骨骼肌指数（aSMI），即手臂和腿部骨骼肌质量/身高。骨质疏松症定义为%YAM<70%，肌少症定义为男性aSMI<7.0kg/m，女性<5.8kg/m，骨质疏松性肌少症定义为同时存在肌少症和骨质疏松症。仅诊断为骨质疏松症的有60例（14%），仅诊断为肌少症的有55例（13%），诊断为骨质疏松性肌少症的有36例（8%）。所有受试者中骨质疏松性肌少症的患病率为8%，女性为12%，男性为4%。骨质疏松性肌少症患者的BMI和背部肌肉力量显著低于仅患肌少症的患者（P<0.05）；骨质疏松性肌少症患者的体重、BMI、体脂、握力和背部肌肉力量显著低于仅患骨质疏松症的患者（P<0.05）。骨质疏松性肌少症与肌肉无力显著相关。需要进一步研究以确定其他相关因素，用于骨质疏松性肌少症的预防和治疗。
