Siu Gillian Denise Ji-Yee, Kam Ka Wai, Young Alvin Lerrmann
a Department of Ophthalmology & Visual Sciences , The Chinese University of Hong Kong , Hong Kong.
b Department of Ophthalmology , Prince of Wales Hospital , Shatin , Hong Kong.
Semin Ophthalmol. 2019;34(3):163-167. doi: 10.1080/08820538.2019.1620790. Epub 2019 May 27.
To assess amniotic membrane retention after amniotic membrane transplant in bullous keratopathy patients and whether there were any corneal structural changes that may hinder further penetrating keratoplasty Methods: A retrospective study including 22 patients who have undergone amniotic membrane transplant from 1 Jan 1998 till 30 Jun 2016. Confocal microscopy and anterior segment optical coherence tomography (ASOCT) were performed to assess the retention of amniotic membrane and to detect any corneal structural changes. The comparison was made with 5 controls who had bullous keratopathy awaiting endothelial keratoplasty.
Patients had a mean follow-up of 61 ± 33.7 months. Pain reduction was significant ( < .001) although it did not significantly correlate with the regularity of the superficial, intermediate or basal epithelial layers, nor with the retention of the amniotic membrane. No long-term structural changes that may hinder future penetrating keratoplasty were detected.
This procedure is a safe and effective long-term treatment for symptomatic bullous keratopathy patients.
评估大疱性角膜病变患者羊膜移植术后羊膜的留存情况，以及是否存在可能妨碍进一步穿透性角膜移植术的角膜结构变化。方法：一项回顾性研究，纳入了1998年1月1日至2016年6月30日期间接受羊膜移植的22例患者。采用共聚焦显微镜检查和眼前节光学相干断层扫描（ASOCT）来评估羊膜的留存情况，并检测角膜的任何结构变化。与5例等待内皮角膜移植术的大疱性角膜病变对照患者进行比较。结果：患者的平均随访时间为61±33.7个月。疼痛减轻显著（P<0.001），尽管其与表层、中层或基底上皮层的规整性以及羊膜的留存均无显著相关性。未检测到可能妨碍未来穿透性角膜移植术的长期结构变化。结论：该手术对于有症状的大疱性角膜病变患者是一种安全有效的长期治疗方法。
