Lalem Torkia, Devaux Yvan
Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg.
Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg.
Clin Biochem. 2019 Aug;70:1-7. doi: 10.1016/j.clinbiochem.2019.05.011. Epub 2019 May 24.
Left ventricular remodeling after acute myocardial infarction affects cardiac function and increases the risk of developing heart failure. Despite the emergence of biomarkers associated with remodeling, the ideal biomarker to accurately predict the risk of developing heart failure after acute myocardial infarction is still to be discovered. Female and male hearts cope differently with ischemic stress, leading to different consequences on cardiac morphology and function. As biomarkers reflect the pathogenesis of remodeling, utilization of sex-specific biomarkers might improve risk stratification. Expressed in cardiac and inflammatory cells, microRNAs regulate several biological pathways triggering the remodeling process. In addition, circulating microRNAs are associated with the risk of developing heart failure after acute myocardial infarction, hence their biomarker potential. Interestingly, multiple microRNAs display sex-specific expression profiles as they can be modulated by sexual hormones and escape X-inactivation, for those located on the X-chromosome. This review article aims to discuss the potential of circulating microRNAs to predict heart failure after acute myocardial infarction in a sex-specific manner.
急性心肌梗死后的左心室重构会影响心脏功能，并增加发生心力衰竭的风险。尽管出现了与重构相关的生物标志物，但准确预测急性心肌梗死后发生心力衰竭风险的理想生物标志物仍有待发现。雌性和雄性心脏对缺血应激的反应不同，导致心脏形态和功能出现不同的后果。由于生物标志物反映了重构的发病机制，使用性别特异性生物标志物可能会改善风险分层。微小RNA在心脏和炎症细胞中表达，可调节触发重构过程的多种生物学途径。此外，循环微小RNA与急性心肌梗死后发生心力衰竭的风险相关，因此具有作为生物标志物的潜力。有趣的是，多种微小RNA表现出性别特异性的表达谱，因为它们可受性激素调节，并且对于位于X染色体上的微小RNA来说，可逃避X染色体失活。这篇综述文章旨在讨论循环微小RNA以性别特异性方式预测急性心肌梗死后心力衰竭的潜力。
